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Lung Cancer
Volume 47, Issue 1
, Pages 129-138
, January 2005
Gefitinib is active in patients with brain metastases from non-small cell lung cancer and response is related to skin toxicity
References
- . Cancer statistics. CA Cancer J. Clin. 2003;53:5–26
- . Frequency, diagnosis, and treatment of brain metastases in 247 consecutive patients with bronchogenic carcinoma. Cancer. 1974;33:492–496
- . Adenocarcinoma of the lung: recent results from the Veterans Administration Lung Group. Am. Rev. Respir. Dis. 1979;120:1025–1029
- . Treatment of brain metastases from primary lung cancer. Int. J. Radiat. Oncol. Biol. Phys. 1995;31:273–278
- . Chemotherapy induces regression of brain metastases in breast carcinoma. Cancer. 1986;58:832–839
- . Successful management of metastatic and primary germ cell tumors in the brain. Cancer. 1986;57:2108–2113
- . Systemic chemotherapy of brain metastases from small-cell lung cancer: a review. J. Clin. Oncol. 1992;10:1498–1502
- Chemotherapy with cisplatin and teniposide for cerebral metastases in non-small cell lung cancer. Lung Cancer. 1998;20:93–98
- First-line chemotherapy with vinorelbine, gemcitabine, and carboplatin in the treatment of brain metastases from non-small-cell lung cancer: a phase II study. Cancer Invest. 2002;20:293–302
- Front-line paclitaxel/cisplatin-based chemotherapy in brain metastases from non-small-cell lung cancer. Oncology. 2003;64:28–35
- Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer. J. Clin. Oncol. 2003;21:2237–2246
- Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial. JAMA. 2003;290:2149–2158
-
Non-small Cell Lung Cancer Collaborative Group. Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised clinical trials. BMJ 1995;311:899–909.
- New guidelines to evaluate the response to treatment in solid tumors. J. Natl. Cancer Inst. 2000;92:205–216
- . Reporting results of cancer treatment. Cancer. 1981;47:207–214
-
.
Quality of life assessment in individuals with lung cancer: testing the lung cancer symptom scale (LCSS).
Eur. J. Cancer. 1993;29A:S51–S58
- ZD1839(‘Iressa’), a selective oral EGFR-TKI (epidermal growth factor receptor tyrosine kinase inhibitor) is well tolerated and active in patients with solid, malignant tumors: results of a phase I trial. J. Clin. Oncol. 2002;20:2240–2250
- Brain tumors in mice are susceptible to blockade of epidermal growth factor receptor (EGFR) with oral, specific, EGFR-tyrosine kinase inhibitor ZD1839 (Iressa). Clin. Cancer Res. 2002;8:3496–3502
- Phase II trial of gefitinib in recurrent glioblastoma. J. Clin. Oncol. 2004;22:133–142
-
Pharmacokinetics of gefitinib in children with brain tumors.
Proc. Am. Soc. Clin. Oncol. 2003;22:132a
- . A case study documenting the anticancer activity of ZD1839 (Iressa) in the brain. Ann. Oncol. 2003;14:656–658
- Epidermal growth factor receptor targeted therapy by ZD1839 (Iressa) in patients with brain metastases from non-small cell lung cancer (NSCLC). Lung Cancer. 2003;41:227–231
- . ZD1839 in patients with brain metastases from non-small cell lung cancer (NSCLC): report of four cases. Br J Cancer. 2003;89:246–247
- . Chemotherapy for brain metastases of lung cancer: a review. Ann Oncol. 1999;10:753–759
-
A retrospective analysis of the outcome of patients (pts) in advanced recurrent adenocarcinoma of the lung who have received gefitinib after treatment of platinum-base regimen.
Proc. Am. Soc. Clin. Oncol. 2003;22:666a
-
.
ZD1839 is more effective in patients with non-small cell lung cancer (NSCLC) who were lifetime non-tobacco users.
Proc. Am. Soc. Clin. Oncol. 2003;22:694a
-
Paez JG, Janne PA, Lee JC, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Sci. Expr. [published online 29 April 2004].
- Severe acute interstitial pneumonia and gefitinib. Lancet. 2003;361:137–139
-
Am epidemiological survey for interstitial lung disease induced by gefitinib in patients with advanced non-small cell lung cancer. West Japan Thoracic Oncology Group (WJTOG).
Eur. J. Cancer Suppl. 2003;1(5):S21
- Phase II trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck. J. Clin. Oncol. 2003;21:1980–1987
- Clinical benefits in patients with advanced non-small-cell lung cancer treated with gefitinib (“Iressa”, ZD1839) in the compassionate use program. Lung Cancer. 2003;41(Suppl 2):S71
- Final results from a phase II study of erlotinib (Tarceva) monotherapy in patients with advanced non-small cell lung cancer following failure of platinum-based chemotherapy. Lung Cancer. 2003;41(Suppl 2):S246–S247
-
.
Rash severity is predictive of increased survival with erlotinib HCl.
Proc. Am. Soc. Clin. Oncol. 2003;22:196a
-
The presence and intensity of the cetuximab-induced acne-like rash predicts increased survival in studies across multiple malignancies.
Proc. Am. Soc. Clin. Oncol. 2003;22:204a
-
Skin toxicity is not a clinical prognostic marker for tumor response to gefitinib (Iressa, ZD1839) in pre-treated patients with advanced non-small cell lung cancer.
Clin. Cancer Res. 2003;9(Suppl 16):70
-
Differential induction of phosphatidylcholine hydrolysis, diacylglycerol formation and protein kinase C activation by epidermal growth factor and transforming growth factor-alpha in normal human skin fibroblasts and keratinocytes.
Biochem. J. 1993;294:535–544
☆ Part of this study has been presented at the 10th World Conference on Lung Cancer, 10–14 August 2003, Vancouver, Canada.
PII: S0169-5002(04)00258-2
doi: 10.1016/j.lungcan.2004.05.014
© 2004 Elsevier Ireland Ltd. All rights reserved.
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Lung Cancer
Volume 47, Issue 1
, Pages 129-138
, January 2005
