Lung Cancer
Volume 55, Issue 1 , Pages 67-73 , January 2007

Clinical significance of a solitary ground-glass opacity (GGO) lesion of the lung detected by chest CT

  • Jin-Young Oh

      Affiliations

    • Division of Pulmonology and Critical Care, Department of Internal Medicine and Lung Institute of Medical Research Center, Seoul National University College of Medicine, Seoul, Republic of Korea
    • Division of Pulmonology, Department of Internal Medicine, Dongguk University College of Medicine, Republic of Korea
  • ,
  • Sung-Youn Kwon

      Affiliations

    • Division of Pulmonology and Critical Care, Department of Internal Medicine and Lung Institute of Medical Research Center, Seoul National University College of Medicine, Seoul, Republic of Korea
    • Department of Medicine, Seoul National University Bundang Hospital, 300 Gumi-Dong, Bundang-Gu, Seongnam 463-707, Republic of Korea
    • Respiratory Center, Seoul National University Bundang Hospital, 300 Gumi-Dong, Bundang-Gu, Seongnam 463-707, Republic of Korea
  • ,
  • Ho-Il Yoon

      Affiliations

    • Division of Pulmonology and Critical Care, Department of Internal Medicine and Lung Institute of Medical Research Center, Seoul National University College of Medicine, Seoul, Republic of Korea
    • Department of Medicine, Seoul National University Bundang Hospital, 300 Gumi-Dong, Bundang-Gu, Seongnam 463-707, Republic of Korea
    • Respiratory Center, Seoul National University Bundang Hospital, 300 Gumi-Dong, Bundang-Gu, Seongnam 463-707, Republic of Korea
  • ,
  • Sang Min Lee

      Affiliations

    • Division of Pulmonology and Critical Care, Department of Internal Medicine and Lung Institute of Medical Research Center, Seoul National University College of Medicine, Seoul, Republic of Korea
  • ,
  • Jae-Joon Yim

      Affiliations

    • Division of Pulmonology and Critical Care, Department of Internal Medicine and Lung Institute of Medical Research Center, Seoul National University College of Medicine, Seoul, Republic of Korea
  • ,
  • Jae-Ho Lee

      Affiliations

    • Division of Pulmonology and Critical Care, Department of Internal Medicine and Lung Institute of Medical Research Center, Seoul National University College of Medicine, Seoul, Republic of Korea
    • Department of Medicine, Seoul National University Bundang Hospital, 300 Gumi-Dong, Bundang-Gu, Seongnam 463-707, Republic of Korea
    • Respiratory Center, Seoul National University Bundang Hospital, 300 Gumi-Dong, Bundang-Gu, Seongnam 463-707, Republic of Korea
  • ,
  • Chul-Gyu Yoo

      Affiliations

    • Division of Pulmonology and Critical Care, Department of Internal Medicine and Lung Institute of Medical Research Center, Seoul National University College of Medicine, Seoul, Republic of Korea
  • ,
  • Young Whan Kim

      Affiliations

    • Division of Pulmonology and Critical Care, Department of Internal Medicine and Lung Institute of Medical Research Center, Seoul National University College of Medicine, Seoul, Republic of Korea
  • ,
  • Sung Koo Han

      Affiliations

    • Division of Pulmonology and Critical Care, Department of Internal Medicine and Lung Institute of Medical Research Center, Seoul National University College of Medicine, Seoul, Republic of Korea
  • ,
  • Young-Soo Shim

      Affiliations

    • Division of Pulmonology and Critical Care, Department of Internal Medicine and Lung Institute of Medical Research Center, Seoul National University College of Medicine, Seoul, Republic of Korea
  • ,
  • Tae Jung Kim

      Affiliations

    • Department of Radiology, Seoul National University Bundang Hospital, 300 Gumi-Dong, Bundang-Gu, Seongnam 463-707, Republic of Korea
  • ,
  • Kyung Won Lee

      Affiliations

    • Department of Radiology, Seoul National University Bundang Hospital, 300 Gumi-Dong, Bundang-Gu, Seongnam 463-707, Republic of Korea
  • ,
  • Jin-Haeng Chung

      Affiliations

    • Department of Pathology, Seoul National University Bundang Hospital, 300 Gumi-Dong, Bundang-Gu, Seongnam 463-707, Republic of Korea
  • ,
  • Sang Hoon Jheon

      Affiliations

    • Respiratory Center, Seoul National University Bundang Hospital, 300 Gumi-Dong, Bundang-Gu, Seongnam 463-707, Republic of Korea
    • Department of Thoracic Surgery, Seoul National University Bundang Hospital, 300 Gumi-Dong, Bundang-Gu, Seongnam 463-707, Republic of Korea
  • ,
  • Sook Whan Sung

      Affiliations

    • Respiratory Center, Seoul National University Bundang Hospital, 300 Gumi-Dong, Bundang-Gu, Seongnam 463-707, Republic of Korea
    • Department of Thoracic Surgery, Seoul National University Bundang Hospital, 300 Gumi-Dong, Bundang-Gu, Seongnam 463-707, Republic of Korea
  • ,
  • Choon-Taek Lee

      Affiliations

    • Division of Pulmonology and Critical Care, Department of Internal Medicine and Lung Institute of Medical Research Center, Seoul National University College of Medicine, Seoul, Republic of Korea
    • Department of Medicine, Seoul National University Bundang Hospital, 300 Gumi-Dong, Bundang-Gu, Seongnam 463-707, Republic of Korea
    • Respiratory Center, Seoul National University Bundang Hospital, 300 Gumi-Dong, Bundang-Gu, Seongnam 463-707, Republic of Korea
    • Corresponding Author InformationCorresponding author at: Department of Medicine, Seoul National University Bundang Hospital, 300 Gumi-Dong, Bundang-Gu, Seongnam 463-707, Republic of Korea. Tel.: +82 31 787 7002; fax: +82 31 787 4052.

Received 23 June 2006 ,Revised 11 September 2006 ,Accepted 18 September 2006.

References 

  1. Kaneko M, Eguchi K, Ohmatsu H, Kakinuma R, Naruke T, Suemasu K, et al. Peripheral lung cancer: screening and detection with low-dose spiral CT versus radiography. Radiology. 1996;201:798–802
  2. Henschke CI, McCauley DI, Yankelevitz DF, Naidich DP, McGuinness G, Miettinen OS, et al. Early Lung Cancer Action Project: overall design and findings from baseline screening. Lancet. 1999;354:99–105
  3. Nagajima R, Yokose T, Kakinuma R, Nagi K, Nishiwaki Y, Ochiai A. Localized pure ground-glass opacity on high-resolution CT: histologic characteristics. J Comput Assist Tomogr. 2002;26:323–329
  4. Austin JH, Muller NL, Friedman PJ, Hansell DM, Naidich DP, Remy-Jardin M, et al. Glossary of terms for CT of the lungs: recommendations of the Nomenclature Committee of the Fleischner Society. Radiology. 1996;200:327–331
  5. Collins J, Stern EJ. Ground-glass opacity at CT: the ABCs. Am J Roentgenol. 1997;169:355–367
  6. Jang HJ, Lee KS, Kwon OJ, Rhee CH, Shim YM, Han J. Bronchioloalveolar carcinoma: focal area of ground-glass attenuation at thin-section CT as an early sign. Radiology. 1996;199:485–488
  7. Kuriyama K, Seto M, Kasugai T, Higashiyama M, Kido S, Sawai Y, et al. Ground-glass opacity on thin-section CT: value in differentiating subtypes of adenocarcinoma of the lung. Am J Roentgenol. 1999;173:465–469
  8. Takashima S, Maruyama Y, Hasegawa M, Saito A. High-resolution CT features: prognostic significance in peripheral lung adenocarcinoma with bronchioloalveolar carcinoma components. Respiration. 2003;70:36–42
  9. Shimizu K, Yamada K, Saito H, Noda K, Nakayama H, Kameda Y, et al. Surgically curable peripheral lung carcinoma: correlation of thin-section CT findings with histologic prognostic factors and survival. Chest. 2005;127:871–878
  10. Kim EA, Johkoh T, Lee KS, Han JH, Fujimoto K, Sadohara J, et al. Quantification of ground-glass opacity on high-resolution CT of small peripheral adenocarcinoma of the lung: pathologic and prognostic implications. Am J Roentgenol. 2001;177:1417–1422
  11. Kodama K, Higashiyama M, Yokouchi H, Takami K, Kuriyama K, Mano M, et al. Prognostic value of ground-glass opacity found in small lung adenocarcinoma on high-resolution CT scanning. Lung Cancer. 2001;33:17–25
  12. Tsubamoto M, Kuriyama K, Kido S, Arisawa J, Kohno N, Johkoh T, et al. Detection of lung cancer on chest radiographs: analysis on the basis of size and extent of ground-glass opacity at thin-section CT. Radiology. 2002;224:139–144
  13. Kakinuma R, Ohmatsu H, Kaneko M, Kusumoto M, Yoshida J, Nakai K, et al. Progression of focal pure ground-glass opacity detected by low-dose helical computed tomography screening for lung cancer. J Comput Assist Tomogr. 2004;28:17–23
  14. Nakata M, Saeki H, Takata I, Segawa Y, Mogami H, Mandai K, et al. Focal ground-glass opacity detected by low-dose helical CT. Chest. 2002;121:1464–1467
  15. Nakata M, Sawada S, Yamashita M, Saeki H, Kurita A, Takashima S, et al. Objective radiologic analysis of ground-glass opacity aimed at curative limited resection for small peripheral non-small cell lung cancer. J Thorac Cardiovasc Surg. 2005;129:1225–1231
  16. Henschke CI, Yankelevitz DF, Mirtcheva R, McGuinness G, McCauley D, Miettinen OS. CT screening for lung cancer: frequency and significance of part-solid and nonsolid nodules. Am J Roentgenol. 2002;178:1053–1057
  17. Minami H, Yoshimura M, Miyamoto Y, Matsuoka H, Tsubota N. Lung cancer in women: sex-associated differences in survival of patients undergoing resection for lung cancer. Chest. 2000;118:1603–1609
  18. Okada M, Nishio W, Sakamoto T, Uchino K, Hanioka K, Ohbayashi C, et al. Correlation between computed tomographic findings, bronchioloalveolar carcinoma component, and biologic behavior of small-sized lung adenocarcinomas. J Thorac Cardiovasc Surg. 2004;127:857–861
  19. Jung KJ, Lee KS, Kim HJ, Kwon OJ, Kim JG, Shim YM, et al. T1 lung cancer on CT: frequency of extrathoracic metastases. J Comput Assist Tomogr. 2000;24:711–718
  20. Matsuguma H, Nakahara R, Anraku M, Kondo T, Tsuura Y, Kamiyama Y, et al. Objective definition and measurement method of ground-glass opacity for planning limited resection in patients with clinical stage IA adenocarcinoma of the lung. Eur J Cardiothorac Surg. 2004;25:1102–1106
  21. Yamada S, Kohno T. Video-assisted thoracic surgery for pure ground-glass opacities 2cm or less in diameter. Ann Thorac Surg. 2004;1911–1915
  22. Nakata M, Sawada S, Saeki H, Takashima S, Mogami H, Teramoto N, et al. Prospective study of thoracoscopic limited resection for ground-glass opacity selected by computed tomography. Ann Thorac Surg. 2003;75:1601–1605
  23. Ginsberg RJ, Rubinstein LV. Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Ann Thorac Surg. 1995;60:615–623

PII: S0169-5002(06)00488-0

doi: 10.1016/j.lungcan.2006.09.009

Lung Cancer
Volume 55, Issue 1 , Pages 67-73 , January 2007