Once-weekly epoetin beta (30,000IU) in anemic patients with lung cancer receiving chemotherapy

Summary 

Anemia occurs frequently in patients with lung cancer receiving chemotherapy and has a negative impact on quality of life (QoL). Erythropoietic proteins effectively increase hemoglobin (Hb) levels, reduce transfusion requirements and improve QoL in anemic patients with a range of malignancies. This prospective, observational study evaluated epoetin beta 30,000IU once weekly in patients with lung cancer in a real-life, clinical-practice setting. Forty patients (72.5% with NSCLC and 27.5% with SCLC) were treated with epoetin beta during any cycle of chemotherapy when Hb decreased to <12g/dL. Hb levels were assessed at regular intervals and transfusion needs were monitored throughout the study. In total, 72.5% of patients required epoetin treatment by the second cycle of chemotherapy. Epoetin beta treatment duration ranged from 1 to >9 (median 4) weeks. Mean (±S.D.) baseline Hb was 10.4±1.2g/dL. Epoetin beta was associated with a rapid increase in Hb levels, with a mean increase of 1.3g/dL by week 4. Most patients (95%) remained transfusion-free throughout the study. Epoetin beta was well tolerated. This early intervention strategy with epoetin beta 30,000IU once weekly is an effective and well-tolerated therapy for anemia in patients with lung cancer.

Keywords: Lung cancer, Epoetin beta, Once weekly, Anemia, Chemotherapy, Clinical setting