Clinicopathological analysis of primary lung carcinoma with heterotopic ossification

Kuribayashi, Hidehiko; Tsuta, Koji; Mizutani, Eiki; Maeshima, Akiko Miyagi; Yoshida, Yukihiro; Gemma, Akihiko; Kudoh, Shoji; Asamura, Hisao; Matsuno, Yoshihiro

doi:10.1016/j.lungcan.2008.08.007

« Previous Next »Lung Cancer
Volume 64, Issue 2 , Pages 160-165, May 2009

Clinicopathological analysis of primary lung carcinoma with heterotopic ossification

Hidehiko Kuribayashi
- Clinical Laboratory Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
- Department of Internal Medicine, Division of Pulmonary Medicine, Infectious Diseases, and Oncology, Nippon Medical School, Tokyo, Japan
Koji Tsuta
- Clinical Laboratory Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
- Corresponding author. Tel.: +81 3 3542 2511; fax: +81 3 3545 3567.
Eiki Mizutani
- Clinical Laboratory Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
- Thoracic Surgery Division, National Cancer Center Hospital, Tokyo, Japan
Akiko Miyagi Maeshima
- Clinical Laboratory Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
Yukihiro Yoshida
- Thoracic Surgery Division, National Cancer Center Hospital, Tokyo, Japan
Akihiko Gemma
- Department of Internal Medicine, Division of Pulmonary Medicine, Infectious Diseases, and Oncology, Nippon Medical School, Tokyo, Japan
Shoji Kudoh
- Department of Internal Medicine, Division of Pulmonary Medicine, Infectious Diseases, and Oncology, Nippon Medical School, Tokyo, Japan
Hisao Asamura
- Thoracic Surgery Division, National Cancer Center Hospital, Tokyo, Japan
Yoshihiro Matsuno
- Clinical Laboratory Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan

Received 26 May 2008; received in revised form 23 July 2008; accepted 2 August 2008. published online 26 September 2008.

Abstract

Pulmonary heterotopic ossification is an unusual event. The relationship between ossification and lung carcinoma is unclear. The present study analyzed clinicopathological features of primary lung carcinoma with heterotopic ossification. We reviewed 2269 surgically resected primary lung carcinomas and identified 33 with heterotopic ossification, including 15 cases with intratumoral heterotopic ossification (IHO) and 18 cases with extratumoral heterotopic ossification (EHO). All cases with IHO were adenocarcinomas and 10 of 15 (66.6%) cases had confirmed positive mucin staining in the tumor cells. Cases with EHO could be divided into three patterns, and each pattern is potentially associated with the background conditions of lung parenchyma. Immunohistochemistry, BMP-2 production was present in 13 of 15 (86.7%) cases with IHO, although, only 4 of 17 (23.5%) cases with EHO. A prognostic analysis revealed no statistically significant difference to be observed between adenocarcinomas with IHO and without IHO. The present study suggested that IHO associated with adenocarcinomas and BMP-2 production in the tumor cells, whereas EHO was not associated with the biology of the carcinoma.

Keywords: Lung cancer, Primary, Ossification, Heterotopic bone formation, BMP-2