Lung Cancer
Volume 67, Issue 3 , Pages 282-289 , March 2010

Structural and biological properties of a papillary component generating a micropapillary component in lung adenocarcinoma

  • Tatsuya Nagano

      Affiliations

    • Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan
    • Thoracic Oncology Division, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    • Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
  • ,
  • Genichiro Ishii

      Affiliations

    • Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan
  • ,
  • Kanji Nagai

      Affiliations

    • Thoracic Oncology Division, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
  • ,
  • Takeo Ito

      Affiliations

    • Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan
    • Thoracic Oncology Division, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
  • ,
  • Akikazu Kawase

      Affiliations

    • Thoracic Oncology Division, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
  • ,
  • Kenji Takahashi

      Affiliations

    • Thoracic Oncology Division, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
  • ,
  • Yoshihiro Nishimura

      Affiliations

    • Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
  • ,
  • Yutaka Nishiwaki

      Affiliations

    • Thoracic Oncology Division, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
  • ,
  • Atsushi Ochiai

      Affiliations

    • Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 4 7134 6855; fax: +81 4 7134 6865.

Received 21 October 2008 ,Revised 3 February 2009 ,Accepted 17 April 2009.

References 

  1. Hoffman PC, Mauer AM, Vokes EE. Lung cancer. Lancet. 2000;355:479–485
  2. Travis WD, Travis LB, Devesa SS. Lung cancer. Cancer. 1995;75:191–202
  3. McDivitt RW, Boyce W, Gersell D. Tubular carcinoma of the breast. Clinical and pathological observations concerning 135 cases. Am J Surg Pathol. 1982;6:401–411
  4. Amin MB, Ro JY, el-Sharkawy T, Lee KM, Troncoso P, Silva EG, et al. Micropapillary variant of transitional cell carcinoma of the urinary bladder. Histologic pattern resembling ovarian papillary serous carcinoma. Am J Surg Pathol. 1994;18:1224–1232
  5. Johansson SL, Borghede G, Holmang S. Micropapillary bladder carcinoma: a clinicopathological study of 20 cases. J Urol. 1999;161:1798–1802
  6. Burks RT, Sherman ME, Kurman RJ. Micropapillary serous carcinoma of the ovary. A distinctive low-grade carcinoma related to serous borderline tumors. Am J Surg Pathol. 1996;20:1319–1330
  7. Eichhorn JH, Bell DA, Young RH, Scully RE. Ovarian serous borderline tumors with micropapillary and cribriform patterns: a study of 40 cases and comparison with 44 cases without these patterns. Am J Surg Pathol. 1999;23:397–409
  8. Silver SA, Askin FB. True papillary carcinoma of the lung: a distinct clinicopathologic entity. Am J Surg Pathol. 1997;21:43–51
  9. Miyoshi T, Satoh Y, Okumura S, Nakagawa K, Shirakusa T, Tsuchiya E, et al. Early-stage lung adenocarcinomas with a micropapillary pattern, a distinct pathologic marker for a significantly poor prognosis. Am J Surg Pathol. 2003;27:101–109
  10. Tsutsumida H, Nomoto M, Goto M, Kitajima S, Kubota I, Hirotsu Y, et al. A micropapillary pattern is predictive of a poor prognosis in lung adenocarcinoma, and reduced surfactant apoprotein A expression in the micropapillary pattern is an excellent indicator of a poor prognosis. Mod Pathol. 2007;20:638–647
  11. Amin MB, Tamboli P, Merchant SH, Ordonez NG, Ro J, Ayala AG, et al. Micropapillary component in lung adenocarcinoma: a distinctive histologic feature with possible prognostic significance. Am J Surg Pathol. 2002;26:358–364
  12. Makimoto Y, Nabeshima K, Iwasaki H, Miyoshi T, Enatsu S, Shiraishi T, et al. Micropapillary pattern: a distinct pathological marker to subclassify tumours with a significantly poor prognosis within small peripheral lung adenocarcinoma (</=20mm) with mixed bronchioloalveolar and invasive subtypes (Noguchi's type C tumours). Histopathology. 2005;46:677–684
  13. Roh MS, Lee JI, Choi PJ, Hong YS. Relationship between micropapillary component and micrometastasis in the regional lymph nodes of patients with stage I lung adenocarcinoma. Histopathology. 2004;45:580–586
  14. Kawakami T, Nabeshima K, Makimoto Y, Hamasaki M, Iwasaki A, Shirakusa T, et al. Micropapillary pattern and grade of stromal invasion in pT1 adenocarcinoma of the lung: usefulness as prognostic factors. Mod Pathol. 2007;20:514–521
  15. Noguchi M, Morikawa A, Kawasaki M, Matsuno Y, Yamada T, Hirohashi S, et al. Small adenocarcinoma of the lung. Histologic characteristics and prognosis. Cancer. 1995;75:2844–2852
  16. In:  Travis WD,  Brambilla E,  Müller-Hermelink HK,  Harris CC editor. Tumours of the lung, pleura, thymus and hearts. Lyon: IAR; 2004;
  17. In:  Sobin LH, Wittekind C  editor. TNM classification of malignant tumors. New York: Wiley and Sons; 2002;
  18. Tsuta K, Ishii G, Nitadori J, Murata Y, Kodama T, Nagai K, et al. Comparison of the immunophenotypes of signet-ring cell carcinoma, solid adenocarcinoma with mucin production, and mucinous bronchioloalveolar carcinoma of the lung characterized by the presence of cytoplasmic mucin. J Pathol. 2006;209:78–87
  19. Kamiya K, Hayashi Y, Douguchi J, Hashiguchi A, Yamada T, Izumi Y, et al. Histopathological features and prognostic significance of the micropapillary pattern in lung adenocarcinoma. Mod Pathol. 2008;
  20. Hoskin PJ, Sibtain A, Daley FM, Wilson GD. GLUT1 and CAIX as intrinsic markers of hypoxia in bladder cancer: relationship with vascularity and proliferation as predictors of outcome of ARCON. Br J Cancer. 2003;89:1290–1297
  21. Cuvier C, Jang A, Hill RP. Exposure to hypoxia, glucose starvation and acidosis: effect on invasive capacity of murine tumor cells and correlation with cathepsin (L+B) secretion. Clin Exp Metastasis. 1997;15:19–25
  22. Harris AL. Hypoxia—a key regulatory factor in tumour growth. Nat Rev Cancer. 2002;2:38–47
  23. Schlappack OK, Zimmermann A, Hill RP. Glucose starvation and acidosis: effect on experimental metastatic potential. DNA content and MTX resistance of murine tumour cells. Br J Cancer. 1991;64:663–670
  24. Eccles SA, Welch DR. Metastasis: recent discoveries and novel treatment strategies. Lancet. 2007;369:1742–1757
  25. Mehlen P, Puisieux A. Metastasis: a question of life or death. Nat Rev Cancer. 2006;6:449–458
  26. Douma S, Van Laar T, Zevenhoven J, Meuwissen R, Van Garderen E, Peeper DS. Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB. Nature. 2004;430:1034–1039
  27. Geiger TR, Peeper DS. The neurotrophic receptor TrkB in anoikis resistance and metastasis: a perspective. Cancer Res. 2005;65:7033–7036
  28. Liotta LA, Kohn E. Anoikis: cancer and the homeless cell. Nature. 2004;430:973–974
  29. Townson JL, Naumov GN, Chambers AF. The role of apoptosis in tumor progression and metastasis. Curr Mol Med. 2003;3:631–642

PII: S0169-5002(09)00251-7

doi: 10.1016/j.lungcan.2009.04.014

Lung Cancer
Volume 67, Issue 3 , Pages 282-289 , March 2010