Down-regulation of HSP27 sensitizes TRAIL-resistant tumor cell to TRAIL-induced apoptosis

Zhuang, Hongqin; Jiang, Weiwei; Cheng, Wei; Qian, Kui; Dong, Wei; Cao, Lin; Huang, Qilai; Li, Shufeng; Dou, Fei; Chiu, Jen-Fu; Fang, Xue-Xun; Lu, Min; Hua, Zi-Chun

doi:10.1016/j.lungcan.2009.05.014

« Previous Next »Lung Cancer
Volume 68, Issue 1 , Pages 27-38, April 2010

Down-regulation of HSP27 sensitizes TRAIL-resistant tumor cell to TRAIL-induced apoptosis

Hongqin Zhuang
- Jiangsu Center of Hepatobiliary Diseases, The State Key Laboratory of Pharmaceutical Biotechnology, College of Life Science, Nanjing University, Nanjing 210093, Jiangsu, PR China
Weiwei Jiang
- Jiangsu Center of Hepatobiliary Diseases, The State Key Laboratory of Pharmaceutical Biotechnology, College of Life Science, Nanjing University, Nanjing 210093, Jiangsu, PR China
Wei Cheng
- Jiangsu Center of Hepatobiliary Diseases, The State Key Laboratory of Pharmaceutical Biotechnology, College of Life Science, Nanjing University, Nanjing 210093, Jiangsu, PR China
Kui Qian
- Jiangsu Center of Hepatobiliary Diseases, The State Key Laboratory of Pharmaceutical Biotechnology, College of Life Science, Nanjing University, Nanjing 210093, Jiangsu, PR China
Wei Dong
- Jiangsu Center of Hepatobiliary Diseases, The State Key Laboratory of Pharmaceutical Biotechnology, College of Life Science, Nanjing University, Nanjing 210093, Jiangsu, PR China
- Department of Chemistry, The School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210093, Jiangsu, PR China
Lin Cao
- Jiangsu Center of Hepatobiliary Diseases, The State Key Laboratory of Pharmaceutical Biotechnology, College of Life Science, Nanjing University, Nanjing 210093, Jiangsu, PR China
Qilai Huang
- Jiangsu Center of Hepatobiliary Diseases, The State Key Laboratory of Pharmaceutical Biotechnology, College of Life Science, Nanjing University, Nanjing 210093, Jiangsu, PR China
Shufeng Li
- Jiangsu Center of Hepatobiliary Diseases, The State Key Laboratory of Pharmaceutical Biotechnology, College of Life Science, Nanjing University, Nanjing 210093, Jiangsu, PR China
- College of Basic Medical Science, Southeast University, Nanjing 210093, Jiangsu, PR China
Fei Dou
- College of Basic Medical Science, Southeast University, Nanjing 210093, Jiangsu, PR China
Jen-Fu Chiu
- Jiangsu Center of Hepatobiliary Diseases, The State Key Laboratory of Pharmaceutical Biotechnology, College of Life Science, Nanjing University, Nanjing 210093, Jiangsu, PR China
- Department of Anatomy, The University of Hong Kong, Hong Kong, China
Xue-Xun Fang
- Jiangsu Center of Hepatobiliary Diseases, The State Key Laboratory of Pharmaceutical Biotechnology, College of Life Science, Nanjing University, Nanjing 210093, Jiangsu, PR China
- Key Laboratory of Molecular Enzymology and Enzyme Engineering of Ministry Education, Jilin University, Changchun 130023, PR China
Min Lu
- Jiangsu Center of Hepatobiliary Diseases, The State Key Laboratory of Pharmaceutical Biotechnology, College of Life Science, Nanjing University, Nanjing 210093, Jiangsu, PR China
Zi-Chun Hua
- Jiangsu Center of Hepatobiliary Diseases, The State Key Laboratory of Pharmaceutical Biotechnology, College of Life Science, Nanjing University, Nanjing 210093, Jiangsu, PR China
- Changzhou High-Tech Research Institute of Nanjing University, Changzhou 213164, Jiangsu, PR China
- Corresponding author at: The State Key Laboratory of Pharmaceutical Biotechnology, College of Life Science, Nanjing University, 22 Han Kou Road, Nanjing 210093, PR China. Tel.: +86 25 83593692; fax: +86 25 83324605.