Lung Cancer
Volume 68, Issue 1 , Pages 72-77 , April 2010

Stereotactic body radiation therapy for early stage non-small cell lung cancer: Results of a prospective trial

  • Umberto Ricardi

      Affiliations

    • Department of Medical and Surgical Sciences, Radiation Oncology Unit, University of Torino, S. Giovanni Battista Hospital, Via Genova, 3, 10126 Torino, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 0116705350; fax: +39 0116638680.
    • ,
  • Andrea Riccardo Filippi

      Affiliations

    • Department of Medical and Surgical Sciences, Radiation Oncology Unit, University of Torino, S. Giovanni Battista Hospital, Via Genova, 3, 10126 Torino, Italy
    • ,
  • Alessia Guarneri

      Affiliations

    • Department of Medical and Surgical Sciences, Radiation Oncology Unit, University of Torino, S. Giovanni Battista Hospital, Via Genova, 3, 10126 Torino, Italy
    • ,
  • Francesca Romana Giglioli

      Affiliations

    • Medical Physics, S. Giovanni Battista Hospital, Torino, Italy
    • ,
  • Patrizia Ciammella

      Affiliations

    • Department of Medical and Surgical Sciences, Radiation Oncology Unit, University of Torino, S. Giovanni Battista Hospital, Via Genova, 3, 10126 Torino, Italy
    • ,
  • Pierfrancesco Franco

      Affiliations

    • Department of Medical and Surgical Sciences, Radiation Oncology Unit, University of Torino, S. Giovanni Battista Hospital, Via Genova, 3, 10126 Torino, Italy
    • ,
  • Cristina Mantovani

      Affiliations

    • Department of Medical and Surgical Sciences, Radiation Oncology Unit, University of Torino, S. Giovanni Battista Hospital, Via Genova, 3, 10126 Torino, Italy
    • ,
  • Piero Borasio

      Affiliations

    • Department of Clinical and Biological Sciences, Thoracic Surgery Unit, University of Torino, S. Luigi Hospital, Orbassano, Italy
    • ,
  • Giorgio Vittorio Scagliotti

      Affiliations

    • Department of Clinical and Biological Sciences, Thoracic Oncology Unit, University of Torino, S. Luigi Hospital, Orbassano, Italy
    • ,
  • Riccardo Ragona

      Affiliations

    • Department of Medical and Surgical Sciences, Radiation Oncology Unit, University of Torino, S. Giovanni Battista Hospital, Via Genova, 3, 10126 Torino, Italy

Received 13 March 2009 ,Revised 14 May 2009 ,Accepted 16 May 2009.

References 

  1. Wisnivesky JP, Bonomi M, Henschke C, Iannuzzi M, McGinn T. Radiation therapy for the treatment of unresected stage I–II non-small cell lung cancer. Chest. 2005;128(3):1461–1467
  2. Blomgren H, Lax I, Naslund I, Svanstrom R. Stereotactic high dose fraction radiation therapy of extracranial tumours using an accelerator; clinical experience on the first thirty-one patients. Acta Oncol. 1995;34:861–870
  3. Lax I, Blomgren H, Naslund I, Svanstrom R. Stereotactic radiotherapy of malignancies in the abdomen: methodological aspects. Acta Oncol. 1994;33:677–683
  4. Slotman B, Antonisse I, Njo K. Limited field irradiation in early stage (T1-2 N0) non-small cell lung cancer. Radiother Oncol. 1996;41:41–44
  5. Wulf J, Haedinger U, Oppitz U, Thiele W, Mueller G, Flientje M. Stereotactic radiotherapy for primary lung cancer and pulmonary metastases: a non-invasive treatment approach in medically inoperable patients. Int J Radiat Oncol Biol Phys. 2004;60:186–196
  6. Nagata Y, Negoro Y, Aoki T, Mizowaki T, Takayama K, Kokubo M, et al. Clinical outcomes of 3D conformal hypofractionated single high-dose radiotherapy for one or two lung tumours using a stereotactic body frame. Int J Radiat Oncol Biol Phys. 2002;52(4):1041–1046
  7. Therasse P, Arbuck SG, Eisenhauer EA, Wanders J, Kaplan RS, Rubinstein L, et al. New guidelines to Evaluate the Response to Treatment in Solid Tumours European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst. 2000;92(3):205–216
  8. Onishi H, Araki T, Shirato H, Nagata Y, Hiraoka M, Gomi K, et al. Stereotactic hypofractionated high-dose irradiation for stage I non-small cell lung carcinoma. Cancer. 2004;101(7):1623–1631
  9. McGarry R, Papiez L, Williams M, Whitford T, Timmerman RD. Stereotactic body radiation therapy of early stage non-small-cell lung carcinoma: phase I study. Int J Radiat Oncol Biol Phys. 2005;63(4):1010–1015
  10. Nagata Y, Takayama K, Matsuo Y, Norihisa Y, Mizowaki T, Sakamoto T, et al. Clinical outcomes of a phase I/II study of 48Gy of stereotactic body radiotherapy in 4 fractions for primary lung cancer using a stereotactic body frame. Int J Radiat Oncol Biol Phys. 2005;63(5):1427–1431
  11. Timmerman R, Papiez L, McGarry R, Likes L, DesRosiers C, Frost S, et al. Extracranial stereotactic radioablation: results of a phase I study in medically inoperable stage I non-small cell lung cancer. Chest. 2003;124:1946–1955
  12. Song DY, Benedict SH, Cardinale RM, Chung TD, Chang MG, Schmidt-Ullrich RK. Stereotactic body radiation therapy of lung tumours: preliminary experience using normal tissue complication probability-based dose limits. Am J Clin Oncol. 2005;28(6):591–596
  13. Hara R, Itami J, Kondo T, Aruga T, Abe Y, Ito M, et al. Stereotactic single high dose irradiation of lung tumours under respiratory gating. Radiother Oncol. 2002;63:159–163
  14. Uematsu M, Shioda A, Suda A, Fukui T, Ozeki Y, Hama Y, et al. Computed tomography-guided frameless stereotactic radiotherapy for stage I non-small cell lung cancer: a 5-year experience. Int J Radiat Oncol Biol Phys. 2001;51:666–670
  15. Nyman J, Johansonn KA, Hulten U. Stereotactic hypofractionated radiotherapy for stage I non-small cell lung cancer—mature results for medically inoperable patients. Lung Cancer. 2006;51:97–103
  16. Beitler JJ, Badine EA, El-Sayah D, Makara D, Friscia P, Silverman P, et al. Stereotactic body radiation therapy for non-metastatic lung cancer: an analysis of 75 patients treated over 5 years. Int J Radiat Oncol Biol Phys. 2006;65:100–106
  17. Hoyer M, Roed H, Traberg Hansen A, Ohlhuis L, Petersen J, Nellemann H, et al. Prospective study on stereotactic radiotherapy of limited stage non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2006;4:S128–S135
  18. Morita K, Fuwa N, Suzuki Y, Nishio M, Sakai K, Tamaki Y, et al. Radical radiotherapy for medically inoperable non-small cell lung cancer in clinical stage I: a retrospective analysis of 149 patients. Radiother Oncol. 1997;42:31–36
  19. Lagerwaard FJ, Haasbeek CJA, Smit EF, Slotman BJ, Senan S. Outcomes of risk-adapted fractionated staereotactic radiotherapy for stage I non-small cell lung cancer. Int J Radiat Oncol Biol Phys. 2008;70(3):685–692
  20. Martini N, Bains MS, Burt ME, Zakowski MF, McCormack P, Rusch VW, et al. Incidence of local recurrence and second primary tumours in resected stage I lung cancer. J Thorac Cardiovasc Surg. 1995;109:120–129
  21. Wisnivesky JP, Yankelevitz D, Henschke CI. The effect of tumour size in curability of stage I non small cell lung cancers. Chest. 2004;126:761–765
  22. Suzuki K, Nagai K, Yoshida J, Nighimura M, Nishiwaki Y. Predictors of lymph node and intrapulmonary metastasis in clinical stage IA non-small cell lung carcinoma. Ann Thorac Surg. 2001;72(2):352–356
  23. Arriagada R, Bergaman B, Dunant A, Le Chevalier T, Pignon JP, Vansteenkiste J. International Adjuvant Lung Cancer Trial Collaborative Group. N Eng J Med. 2004;350(4):351–360
  24. Douillard JY, Rosell R, De Lena M, Carapagnano F, Ramaiu R, Gonzales-Larriba JL, et al. Adjuvant vinorelbine plus cisplatin versus observation in patients with completely resected stage IB-IIIA non-small cell lung cancer/Adjuvant Navelbine International Trialist Association (ANITA): a ransomised controlled trial. Lancet Oncol. 2006;7(9):719–727
  25. Pignon JP, Tribodet H, Scagliotti GV, Douillard JY, Shepherd FA, Stephens RJ, et al. Lung adjuvant cisplatin evaluation: a pooled analysis by the LACE Collaborative Group. J Clin Oncol. 2008;26(21):3552–3559
  26. Ricardi U, Filippi AR, Guarneri A, Giglioli FR, Mantovani C, Fiandra C, et al. Dosimetric predictors of radiation-induced lung injury in stereotactic body radiation therapy. Acta Oncol. 2008;27:1–7
  27. Ohashi T, Takeda A, Shigematsu N, Kunieda E, Ishizaka A, Fukada J, et al. Differences in pulmonary function before vs. 1 year after hypofractionated stereotactic radiotherapy for small peripheral lung tumours. Int J Radiat Oncol Biol Phys. 2005;62(4):1003–1008
  28. McGarry RC, Papiez L, Williams M, Whitford T, Timmermann RD. Stereotactic body radiation therapy of early stage non-small cell lung carcinoma: phase I study. Int J Radiat Oncol Biol Phys. 2005;63(4):1010–1015

PII: S0169-5002(09)00310-9

doi: 10.1016/j.lungcan.2009.05.007

Lung Cancer
Volume 68, Issue 1 , Pages 72-77 , April 2010

Article Tools

* Image Usage & Resolution