EUS-FNA in the preoperative staging of non-small cell lung cancer
Received 30 June 2009; received in revised form 15 August 2009; accepted 19 August 2009. published online 17 September 2009.
Abstract
Background
According to current guidelines, transesophageal ultrasound-guided fine needle aspiration (EUS-FNA) can be performed as an alternative for surgical staging to confirm mediastinal metastases in patients with non-small cell lung cancer (NSCLC). To date however, data regarding the routine use of EUS-FNA in the preoperative staging of unselected patients with NSCLC are limited.
Aims and objectives
(1)To evaluate the diagnostic value of EUS-FNA in consecutive, patients with NSCLC regardless of nodal size at CT.
(2)To determine the impact of EUS-FNA on the prevention of surgical staging procedures.
(3)To assess the accuracy of mediastinal staging by combining EUS-FNA and mediastinoscopy.
(4)To investigate whether a subgroup of patients exists that can be accurately staged by EUS-FNA alone.
Methods
152 consecutive operable patients with proven or suspected NSCLC who underwent EUS-FNA were retrospectively analyzed. In the absence of mediastinal metastases, mediastinoscopy and/or thoracotomy with lymph node dissection was performed.
Results
The prevalence of mediastinal metastases was 49%. Sensitivity, negative predictive value (NPV) and accuracy of EUS-FNA for N2/N3 disease were 74%, 73% and 85% respectively, whereas these values for the combined staging of EUS-FNA and mediastinoscopy were 92%, 85% and 95%. Additional surgical staging in patients staged N0 at EUS-FNA reduces the false negative EUS-findings by 55%. The NPV of EUS-FNA for left-sided tumors was 68%. EUS-FNA prevented surgical staging procedures in 60 of 152 patients (39%). No major complications occurred during EUS-FNA.
Conclusion
Routine use of EUS-FNA in unselected patients with NSCLC reduces the need for surgical staging procedures in nearly half of patients. Additional surgical staging in patients without nodal metastases at EUS-FNA reduces the false negative EUS-FNA findings considerably regardless of the location of the primary lung tumor.
aDepartment of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
bDepartment of Cardio-thoracic Surgery, Leiden University Medical Center, Leiden, The Netherlands
cDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
Corresponding author at: Department of Pulmonology, Leiden University Medical Center, Staf longziekten C3-P, Leiden, Netherlands. Tel.: +31 71 526 2950; fax: +31 71 526 6927.
ABSTRACT