Lung Cancer
Volume 69, Issue 1 , Pages 51-53 , July 2010

KRAS mutation, KRAS–LCS6 polymorphism, and non-small cell lung cancer

  • H.H. Nelson

      Affiliations

    • Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55455, United States
    • Corresponding Author InformationCorresponding author.
    • ,
  • B.C. Christensen

      Affiliations

    • Department of Pathology and Laboratory Medicine, Center for Environmental Health and Technology, Brown University, Providence, RI 02912, United States
    • Department of Community Health, Center for Environmental Health and Technology, Brown University, Providence, RI 02912, United States
    • ,
  • S.L. Plaza

      Affiliations

    • Department of Pathology and Laboratory Medicine, Center for Environmental Health and Technology, Brown University, Providence, RI 02912, United States
    • ,
  • J.K. Wiencke

      Affiliations

    • Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, United States
    • ,
  • C.J. Marsit

      Affiliations

    • Department of Pathology and Laboratory Medicine, Center for Environmental Health and Technology, Brown University, Providence, RI 02912, United States
    • ,
  • K.T. Kelsey

      Affiliations

    • Department of Pathology and Laboratory Medicine, Center for Environmental Health and Technology, Brown University, Providence, RI 02912, United States
    • Department of Community Health, Center for Environmental Health and Technology, Brown University, Providence, RI 02912, United States

Received 27 April 2009 ,Revised 25 August 2009 ,Accepted 19 September 2009.

References 

  1. Esquela-Kerscher A, Slack F. Oncomirs: microRNAs with a role in cancer. Nat Rev Cancer. 2006;6:259–269
  2. Kumar M, Erkeland SJ, Pester RE, Chen CY, Ebert MS, Sharp PA, et al. Suppression of non-small cell lung tumor development by the let-7 micro-RNA family. PNAS. 2008;105:3903–3908
  3. Takamizawa J, Konishi H, Yanagisawa K, Tomida S, Osada H, Endoh E, et al. Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res. 2004;64:3753–3756
  4. Johnson S, Grosshans H, Shingara J, Byrom M, Jarvis R, Cheng A, et al. RAS is regulated by the let-7 microRNA family. Cell. 2005;120:635–647
  5. Nelson HHCD, Mark EJ, Wiencke JK, Wain JC, Kelsey KT. Implications and prognostic value of K-ras mutation for early-stage lung cancer in women. J Natl Cancer Inst. 1999;91:2032–2038
  6. Yanaihara N, Caplen N, Bowman E, Seike M, Kumamoto K, Yi M, et al. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell. 2006;9:189–198
  7. Chin L, Ratner E, Leng S, Zhai R, Nallur S, Babar I, et al. A SNP in a let-7 microRNA complementary site in the kras 3′ untranslated region increases non-small cell lung cancer risk. Cancer Res. 2008;68:8535–8540
  8. Tokumaru S, Suzuki M, Yamada H, Nagino M, Takahashi T. let-7 regulates Dicer expression and constitutes a negative feedback loop. Carcinogenesis. 2008;[Epub August 11]
  9. Christensen BC, Moyer BJ, Avissar M, Ouellet LG, Plaza S, McClean MD, et al. A let-7 microRNA binding site polymorphism in the KRAS 3′ UTR is associated with reduced survival in oral cancers. Carcinogenesis. 2009;30(6):1003–1007

PII: S0169-5002(09)00492-9

doi: 10.1016/j.lungcan.2009.09.008

Lung Cancer
Volume 69, Issue 1 , Pages 51-53 , July 2010

Article Tools

* Image Usage & Resolution