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Lung Cancer
Volume 67, Issue 3
, Pages 257-274
, March 2010
Targeted therapies for non-small cell lung cancer
References
- . Systemic chemotherapy for advanced non-small cell lung cancer: recent advances and future directions. Oncologist. 2008;15:5–13
- . Second-line chemotherapy for non-small cell lung cancer. Expert Rev Anticancer Ther. 2003;3:435–442
- American Society of Clinical Oncology treatment of unresectable non-small-cell lung cancer guideline: update 2003. J Clin Oncol. 2003;21:330–353
- Comparison of four chemotherapy regimes for advanced non-small cell lung cancer. N Engl J Med. 2002;346:92–98
- . Duration of chemotherapy for advanced non-small-cell lung cancer: a systematic review and meta-analysis of randomized trials. J Clin Oncol. 2009;27:3277–3283
- Gemcitabine plus carboplatin versus mitomycin, ifosfamide, and cisplatin in patients with stage IIIB or IV non small cell lung cancer. A phase III randomized study of the London Cancer Group. J Clin Oncol. 2005;23:142–153
- Multicentre randomized phase III study comparing the same dose and schedule of cisplatin plus the same schedule of vinorelbine or gemcitabine in advanced non-small cell lung cancer. Eur J Cancer. 2005;41:81–92
- . Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomized clinical trials. BMJ. 1995;311:899–909
- . Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets. Nat Med. 2000;6:443–446
- Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med. 2009;360:1408–1417
- . Cetuximab and other anti-epidermal growth factor receptor monoclonal antibodies in the treatment of non-small cell lung cancer. Oncologist. 2009;14:601–611
- Randomized phase II study of cetuximab plus cisplatin/vinorelbine compared with cisplatin/vinorelbine alone as first-line therapy in EGFR-expressing advanced non-small-cell lung cancer. Ann Oncol. 2008;19:362–369
- Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomized phase III trial. Lancet. 2009;373:1525–1531
- . A randomized multicenter phase III study of cetuximab (Erbitux®) in combination with taxane/carboplatin versus taxane/carboplatin alone as first-line treatment for patients with advanced/metastatic non-small cell lung cancer (NSCLC). J Thorac Oncol. 2007;2(8 Suppl. 4):340
- Thatcher N, Lynch T, Butts C, Scott DA, Woods BS. Cetuximab plus platinum-based chemotherapy as 1st-line treatment in patients with non-small cell lung cancer (NSCLC): a meta-analysis of randomized phase II/III trials. 13th WCLC 2009; #A3.7.
- Summary statement novel agents in the treatment of lung cancer. J Thorac Oncol. 2008;6(6 Suppl. 2):107–112
- . Recent advances of novel targeted therapy in non-small cell lung cancer. J Hema Oncol. 2009;2:2–20
- Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol. 2004;22:2184–2191
- Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med. 2006;355:2542–2550
- Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAiL. J Clin Oncol. 2009;27:1227–1234
- . ECOG 4599 phase III trial of carboplatin and paclitaxel
±
bevacizumab: subset analysis of survival by gender. J Clin Oncol. 2006;24(Suppl.):7036 - . Subgroup results from a randomised, double-blind, multicentre phase III study of bevacizumab in combination with cisplatin-gemcitabine in chemotherapy-naïve patients with advanced or recurrent non-squamous nonsmall cell lung cancer (NSCLC): study BO17704. Eur J Cancer. 2007;5(Suppl.):362
- Outcomes for elderly, advanced-stage non-small-cell lung cancer patients treated with bevacizumab in combination with carboplatin and paclitaxel: analysis of Eastern Cooperative Oncology Group trial 4599. J Clin Oncol. 2008;26:60–65
- . MO19390 (SAiL): safety and efficacy of first-line bevacizumab (BV)-based therapy in advanced non-small cell lung cancer (NSCLC). J Clin Oncol. 2009;27(Suppl.):8043
- Preliminary safety and effectiveness of bevacizumab (BV) based treatment in subpopulations of patients (pts) with non-small cell lung cancer (NSCLC) from the ARIES study: a bevacizumab (BV) treatment observational cohort study (OCS). J Clin Oncol. 2009;27(Suppl.):8040
- Acceptable safety of bevacizumab therapy in patients with brain metastases due to non-small cell lung cancer. J Clin Oncol. 2008;26(Suppl.):8043
- . A randomized, double-blind, placebo-controlled, phase IIIb trial (ATLAS) comparing bevacizumab (B) therapy with or without erlotinib (E) after completion of chemotherapy with B for first-line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer (NSCLC). J Clin Oncol. 2009;27(Suppl.):8002
- . A phase III multicenter, placebo-controlled, double-blind, randomized clinical trial to evaluate the efficacy of bevacizumab (Avastin®) in combination with erlotinib (Tarceva®) compared with erlotinib alone for treatment of advanced non-small cell lung cancer after failure of standard first-line chemotherapy (BETA). J Thorac Oncol. 2008;3(Suppl. 4):S302
- . Resistance to EGF-R (erbB-1) and VEGF-R modulating agents. Eur J Cancer. 2009;45:1117–1128
- Acquired resistance to EGFR-tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins. J Clin Invest. 2008;118:2609–2619
- . Insulin-like growth factor 1 receptor targeted therapeutics: novel compounds and novel treatment strategies for cancer medicine. Recent Pat Anticancer Drug Discov. 2009;4:54–72
- Phase I dose escalation trial of the anti insulin-like growth factor-I receptor monoclonal antibody CP-751,871 in patients with refractory solid tumors. Clin Cancer Res. 2007;13:5834–5840
- Phase I, pharmacokinetic and pharmacodynamic study of the anti-insulin like growth factor type 1 receptor monoclonal antibody CP-751,871 in patients with multiple myeloma. J Clin Oncol. 2008;26:3196–3202
- Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer. J Clin Oncol. 2009;27:2515–2522
- . The prognostic significance of pretreatment plasma levels of insulin-like growth factor (IGF)-1, IGF-2, and IGF binding protein-3 in patients with advanced non-small cell lung cancer. Lung Cancer. 2006;54:227–234
- First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations. J Clin Oncol. 2008;26:2442–2449
- Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinoma with acquired resistance to kinase inhibitors. Clin Cancer Res. 2006;12:6494–6501
- . Mutations in the epidermal growth factor receptor gene and effects of EGFR-tyrosine kinase inhibitors on lung cancer. Gen Thorac Cardiovasc Surg. 2008;56:97–103
- Analysis of epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer and acquired resistance to gefitinib. Clin Cancer Res. 2006;12:5764–5769
- Multi-Institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer. J Clin Oncol. 2003;21:2237–2246
- . Getting the grips with gefitinib. Lancet Oncol. 2003;4:719–720
- . Quantitative gene expression in non-small cell lung cancer from paraffin-embedded tissue specimen: predicting response to gefitinib, an EGFR kinase inhibitor. Lung Cancer. 2003;41(Suppl. 2):S71–S72
- EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science. 2004;304:1497–1500
- . Molecular predictors of response to epidermal growth factor receptor antagonists in non-small-cell lung cancer. J Clin Oncol. 2007;25:587–595
- Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial—INTACT 2. J Clin Oncol. 2004;22:785–794
- Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survial Evaluation in Lung Cancer). Lancet. 2005;366:1527–1537
- Gefitinib (IRESSA) in patients of Asian origin with refractory advanced non-small cell lung cancer: subset analysis from the ISEL trial. J Thorac Oncol. 2006;1:847–855
- . Biological and clinical implications of EGFR mutations in lung cancer. Int J Clin Oncol. 2006;11:190–198
- . Phase II, open-label, randomized study (SIGN) of single-agent gefitinib (IRESSA) or docetaxel as second-line therapy in patients with advanced (stage IIIb or IV) non-small-cell lung cancer. Anticaner Drugs. 2006;17:401–409
- Phase III study, V-15-32, of gefitinib versus docetaxel in previously treated Japanese patients with non-small-cell lung cancer. J Clin Oncol. 2008;26:4244–4252
- Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): a randomised phase III trial. Lancet. 2008;372:1809–1818
- First-line gefitinib for patients with advanced non-small-cell lung cancer harboring epidermal growth factor receptor mutations without indication for chemotherapy. J Clin Oncol. 2009;27:1394–1400
- Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med. 2009;361:1018–1020
- Biomarker analyses from a phase III, randomized, open-label, first-line study of gefitinib (G) versus carboplatin/paclitaxel (C/P) in clinically selected patients (pts) with advanced non-small cell lung cancer (NSCLC) in Asia (IPASS). J Clin Oncol. 2009;27(Suppl.):15
- First-line gefitinib versus first-line chemotherapy by carboplatin (CBDCA) plus paclitaxel (TXL) in non-small cell lung cancer (NSCLC) patients with EGFR mutations: a phase III study (002) by North east Japan Gefitinib Study Group. J Clin Oncol. 2009;27(Suppl.):15s
- Determinants of tumor response and survival with erlotinib in patients with non-small-cell lung cancer. J Clin Oncol. 2004;22:3238–3247
- Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med. 2005;353:123–132
- Symptom improvement in lung cancer patients treated with erlotinib: quality of life analysis of the National Cancer institute of Canada Clinical Trials Group Study BR.21. J Clin Oncol. 2006;24:3831–3837
- Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol. 2007;25:1960–1966
- . Global efficacy and safety results from the TRUST study of erlotinib monotherapy in >7000 patients (pts) with non-small cell lung cancer (NSCLC). ESMO. 2008;262P
- . Clinical benefit of erlotinib in male smokers with squamous-cell carcinoma. J Clin Oncol. 2006;24(Suppl.):7166
- Effects of smoking on the pharmacokinetics of erlotinib. Clin Cancer Res. 2006;12:2166–2171
- Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21. J Clin Oncol. 2008;26:4268–4275
- Screening for epidermal growth factor receptor mutations in lung cancer. N Engl J Med. 2009;361:958–967
- SATURN: a double-blind, randomized, phase III study of maintenance erlotinib versus placebo following nonprogression with first-line platinum-based chemotherapy in patients with advanced NSCLC. J Clin Oncol. 2009;27(Suppl.):8001
- Biomarker analyses from the phase III placebo-controlled SATURN study of maintenance erlotinib following first-line chemotherapy for advanced NSCLC. J Clin Oncol. 2009;27(Suppl.):8020
- . Molecular markers and clinical outcome with erlotinib: results from the phase III placebo-controlled SATURN study of maintenance therapy for advanced NSCLC. WCLC. 2009;B9.1
- . Lung cancer. N Engl J Med. 2008;359:1367–1380
- . BIBW-2992, a dual receptor tyrosine kinase inhibitor for the treatment of solid tumors. Curr Opin Investig Drugs. 2008;9:1336–1346
- A phase I dose escalation study of BIBW 29992, an irreversible dual inhibitor of epidermal growth factor receptor I (EGFR) and 2 (HER2) tyrosine kinase in a 2-week on, 2-week off schedule in patients with advanced solid tumours. Br J Cancer. 2008;98:80–85
- Phase IIb/III double-blind randomized trial of BIBW 2992, an irreversible, dual inhibitor of EGFR and HER2 plus best supportive care (BSC) versus placebo plus BSC in patients with NSCLC failing 1–2 lines of chemotherapy (CT) and erlotinib or gefitinib (LUX-Lung 1): a preliminary report. J Clin Oncol. 2009;27(Suppl.):422s
- http://www.boehringer-ingelheim.com
- . Novel therapeutic inhibitors of the c-Met signaling pathway in cancer. Clin Cancer Res. 2009;15:2207–2214
- . Synergism of EGFR and c-Met pathways, cross-talk and inhibition, in non-small cell lung cancer. J Carcinogenesis. 2008;7:1–8
- MET amplification occurs with or without T790M mutation in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. PNAS. 2007;52:20932–20937
- . Met pathway as a therapeutic target. J Thorac Oncol. 2009;4:444–447
- Clinical activity observed in a phase 1 dose-escalation trial of an oral MET and ALK inhibitor, PF-02341066. J Clin Oncol. 2009;27(Suppl.):3509
- . Review: monoclonal antibodies to the vascular endothelial growth factor receptor-2 in cancer therapy. Clin Cancer Res. 2007;18(Suppl.):5544s–5548s
- . Molecular mechanisms of lymphangiogenesis in health and disease. Cancer Cell. 2002;3:219–227
- . Tumor angiogenesis. New Engl J Med. 2008;358:2039–2049
- AZD2171. A highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res. 2005;65:4389–4400
- Phase I and pharmacokinetic study of daily oral AZD2171, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with carboplatin and paclitaxel in patients with advanced non-small-cell lung cancer: The National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol. 2008;26:1871–1878
- . Randomizes, double-blind phase II trial of carboplatin
+
paclitaxel (C
+
P) with either daily oral cediranib, an inhibitor of vascular endothelial growth factor receptor [VEGFR] tyrosine kinases. Ann Oncol. 2009;19(Suppl. 8):90–91 - Vandetanib in metastatic hereditary medullary thyroid cancer: follow-up results of an open-label phase II trial. J Clin Oncol. 2007;25(Suppl.):6018
- Randomized, placebo-controlled phase II study of vandetanib plus docetaxel in previously treated non small-cell lung cancer. J Clin Oncol. 2007;25:4270–4277
- Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small cell lung cancer (NSCLC): a randomized, double-blind phase III trial (ZODIAC). J Clin Oncol. 2009;27(Suppl.):407s
- Vandetanib plus pemetrexed versus pemetrexed as second-line therapy in patients with advanced non-small cell lung cancer (NSCLC): a randomized, double-blind phase III trial (ZEAL). J Clin Oncol. 2009;27(Suppl.):8010
- Vandetanib versus erlotinib in patients with advanced non-small cell lung cancer (NSCLC) after failure of at least one prior cytotoxic chemotherapy: a randomized, double-blind phase III trial (ZEST). J Clin Oncol. 2009;27(Suppl.):8009
- Targeted therapy against VEGFR and EGFR with ZD6474 enhances the therapeutic efficacy of irradiation in an orthotopic model of human non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2007;69:1534–1543
- . Combined inhibition of the VEGFR and the EGFR signalling pathways in treatment of the NSCLC. Oncologist. 2009;14:399–411
- Phase I multicenter trial of BMS-690514: safety, pharmacokinetic profile, biological effects, and early clinical evaluation in patients with advanced solid tumors and non-small cell lung cancer. J Clin Oncol. 2008;26(Suppl.):2564
- Tumor regression and pharmacodynamic (PD) biomarker validation in non-small cell lung cancer (NSCLC) patients treated with the ErbB/VEGFR inhibitor BMS-690514. J Clin Oncol. 2009;27(Suppl.):431s
- BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res. 2008;68:4774–4782
- Pharmacokinetic (PK) analysis of a phase I study of continuous oral treatment with the angiokinase inhibitor BIBF 1120, in combination with carboplatin and paclitaxel in patients with advanced non-small cell lung cancer (NSCLC). J Clin Oncol. 2008;26(Suppl.):3567
- Population pharmacokinetic analysis for BIBF 1120, an angiokinase inhibitor, in patients with advanced non-small-cell lung cancer (NSCLC). J Clin Oncol. 2008;26(Suppl.):14528
- Sorafenib and sunitinib in the treatment of advanced non-small cell lung cancer. Oncologist. 2007;12:191–200
- . The current status and evolving role of sunitinib in non-small cell lung cancer. J Thorac Oncol. 2008;3(6 Suppl. 2):119–123
- New avenues for second-line treatment of metastatic non-small cell lung cancer. Expert Rev Anticancer Ther. 2009;9:115–124
- Multicenter, phase II trial of sunitinib in previously treated, advanced non-small-cell lung cancer. J Clin Oncol. 2008;26:650–656
- A phase II study of continuous daily sunitinib dosing in patients with previously-treated advanced non-small cell lung cancer (NSCLC). J Thorac Oncol. 2007;2(Suppl. 4):S470
- http://www.suntrials.com
- Phase II trial of single-agent sorafenib in patients with advanced non-small cell lung carcinoma. J Clin Oncol. 2006;24(Suppl. 18):7002
- Sorafenib combined with carboplatin/paclitaxel for advanced non-small cell lung cancer: a phase I subset analysis. J Clin Oncol. 2006;24(Suppl. 18):7194
- A front-line window of opportunity phase II study of sorafenib in patients with advanced non-small cell lung cancer: a north central cancer treatment group study. J Clin Oncol. 2007;25(Suppl. 18):7547
- Broad antitumor activity in breast cancer xenografts by motesanib, a highly selective, oral inhibitor of vascular endothelial growth factor, platelet-derived growth factor, and KIT receptors. Clin Cancer Res. 2009;15:110–118
- . Targeting the mTOR signaling network for cancer therapy. J Clin Oncol. 2009;27:2278–2287
- . Ras, PI(3)K and mTOR signalling controls tumour growth. Nature. 2006;441:424–430
- Phase I/II study of the mammalian target of rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies. Clin Cancer Res. 2006;12:5165–5173
- Phase II study with temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer. J Clin Oncol. 2005;23:5314–5322
- . The potential role of mTOR inhibitors in non-small cell lung cancer. Oncologist. 2008;13:139–147
- Everolimus restores gefitinib sensitivity in resistant non-small cell lung cancer cell lines. Biochem Pharmacol. 2009;78:460–468
- . Rationale for a phase I trial or erlotinib and the mammalian target of rapamycin inhibitor everolimus (RAD001) for patients with relapsed non-small cell lung cancer. Clin Cancer Res. 2007;13(Suppl. 15):4628s–4631s
- Phase 1 trial of everolimus and gefitinib in patients with advanced nonsmall-cell lung cancer. Cancer. 2007;110:599–605
- Everolimus, an mTOR inhibitor, in combination with docetaxel for recurrent/refractory NSCLC: a phase I study. J Clin Oncol. 2009;27(Suppl.):421s
- Efficacy of everolimus (RAD001) in patients with advanced NSCLC previously treated with chemotherapy alone or with chemotherapy and EGFR inhibitors. Ann Oncol. 2009;(published electronically (June 23))
- . Clinical development of histone deacetylase inhibitors as anticancer agents. Ann Rev Pharmacol Toxicol. 2005;45:495–528
- . Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat Rev Cancer. 2006;6:38–51
- . The potential role of histone deacetylase inhibitors in the treatment of non-small-cell lung cancer. Crit Rev Oncol Hematol. 2008;68:29–36
- Early phase II trial of oral vorinostat in relapsed or refractory breast, colorectal, or non-small cell lung cancer. Invest New Drugs. 2008;26:483–488
- Vorinostat (NSC#701852) in patients with relapsed non-small cell lung cancer: a Wisconsin Oncology Network phase II study. J Thorac Oncol. 2009;4:522–526
- Randomized, double-blind, placebo-controlled phase II study on carboplatin and paclitaxel with or without vorinostat, a histone deacetylase inhibitor (HDAC), for first-line therapy of advanced non-small cell lung cancer (NCI 7863). J Clin Oncol. 2009;27(Suppl.):408s
- . Vascular integrins in tumor angiogenesis: mediators and therapeutic targets. Endothelium. 2006;13:113–135
- . Cilgengitide (Merck). Curr Opin Investig Drugs. 2003;4:741–745
- Phase I and correlative biology study of cilengitide in patients with recurrent glioma. J Clin Oncol. 2007;25:1651–1657
- Randomized phase II study of three doses of the integrin inhibitor cilengitide versus docetaxel as second-line treatment for patients with stage IV non-small cell lung cancer (NSCLC). J Clin Oncol. 2009;27(Suppl.):410s
- Inhibition of alpha(v)beta3 integrin survival signaling enhances antiangiogenetic and antitumor effects of radiotherapy. Clin Cancer Res. 2005;11:6270–6279
- . Integrin alpha v beta antagonist cilengitide enhances efficacy of radiotherapy in endothelial cell and non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2006;65:1536–1543
- . Biology of osteoclast activation in cancer. J Clin Oncol. 2001;19:3562–3571
- . Osteoclast differentiation and activation. Nature. 2003;423:337–342
- . Mechanism of hypercalcemia in adult T-cell leukemia. Overexpression of receptor activator of nuclear factor κB ligand on adult T cell leukemia cells. Blood. 2002;99:634–640
- OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymphnode organogenesis. Nature. 1999;397:315–323
- Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Gene Dev. 1998;12:1260–1268
- Mixed metastatic lung cancer lesions in bone are inhibited by noggin overexpression and Rank:Fc administration. J Bone Miner Res. 2006;21:1571–1580
- . RANK is expressed in human lung tumours and it functional on human lung cancer cells. Cancer Treat Rev. 2006;32(Suppl. 3):S45
- . RANKL inhibition blocks lung cancer-induced osteolytic lesions and reduces skeletal tumor burden in both RANK-expression and RANK-negative lung cancers. ASBMR. 2007;22:S114
- A phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastasis. Cancer. 2003;97:887–892
- Randomized phase II trial of denosumab in patients with bone metastases from prostate cancer, breast cancer, or other neoplasms after intravenous bisphosphonates. J Clin Oncol. 2009;27:1564–1571
- . Incorporating bortezomib into the treatment of lung cancer. Clin Cancer Res. 2007;13(Suppl. 15):s4647–s4651
- Randomized phase II study of bortezomib alone and bortezomib in combination with docetaxel in previously treated advanced non-small-cell lung cancer. J Clin Oncol. 2006;24:5025–5033
- Bortezomib plus gemcitabine/carboplatin as first-line treatment of advanced non-small cell lung cancer: a phase II Southwest Oncology Group Study (S0339). J Thorac Oncol. 2009;41:87–92
- Phase II study of the proteasome inhibitor bortezomib (PS-341, Velcade®) in chemotherapy-naïve patients with advanced stage no-small cell lung cancer (NSCLC). Lung Cancer. 2009;(published electronically (June 11))
- . Targeted anti-mitotic therapies: can we improve on tubulin agents?. Nat Rev Cancer. 2007;7:107–117
- . A phase I pharmacokinetic study of HMN-214, a novel oral stilbene derivative with polo-like kinase-1 interacting properties, in patients with advanced solid tumors. Clin Cancer Res. 2006;12:5182–5189
- BI 6727, a polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity. Clin Cancer Res. 2009;15:3094–3102
- . Polo-like kinase (PLK) inhibitors in preclinical and early clinical development in oncology. Oncologist. 2009;14:559–570
- BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo. Curr Biol. 2007;17:316–322
- Randomized phase II trial of two dosing schedules of BI 2536, a novel Plk-1 inhibitor, in patients with relapsed advanced or metastatic non-small cell lung cancer (NSCLC). J Clin Oncol. 2008;26(Suppl.):8030
- . To kill a tumor cell: the potential of proapoptotic receptor agonists. J Clin Invest. 2008;118:1979–1990
- First-in-human study of AMG655, a pro-apoptotic TRAIL receptor-2 agonist, in adult patients with advanced solid tumors. J Clin Oncol. 2007;25(Suppl.):3534
- Safety and efficacy of AMG655 in combination with paclitaxel and carboplatin (PC) in patients with advanced non-small cell lung cancer (NSCLC). J Clin Oncol. 2009;27(Suppl.):19048
PII: S0169-5002(09)00543-1
doi: 10.1016/j.lungcan.2009.10.012
© 2009 Elsevier Ireland Ltd. All rights reserved.
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Lung Cancer
Volume 67, Issue 3
, Pages 257-274
, March 2010
