Lung Cancer
Volume 70, Issue 1 , Pages 28-36 , October 2010

Human umbilical cord matrix-derived stem cells expressing interferon-β gene significantly attenuate bronchioloalveolar carcinoma xenografts in SCID mice

  • Takaya Matsuzuka

      Affiliations

    • Department of Anatomy & Physiology, College of Veterinary Medicine, Kansas State University, 1600 Denison Ave, Manhattan, KS 66506, USA
    • ,
  • Raja Shekar Rachakatla

      Affiliations

    • Department of Anatomy & Physiology, College of Veterinary Medicine, Kansas State University, 1600 Denison Ave, Manhattan, KS 66506, USA
    • ,
  • Chiyo Doi

      Affiliations

    • Department of Anatomy & Physiology, College of Veterinary Medicine, Kansas State University, 1600 Denison Ave, Manhattan, KS 66506, USA
    • ,
  • Dharmendra Kumar Maurya

      Affiliations

    • Department of Anatomy & Physiology, College of Veterinary Medicine, Kansas State University, 1600 Denison Ave, Manhattan, KS 66506, USA
    • ,
  • Naomi Ohta

      Affiliations

    • Department of Anatomy & Physiology, College of Veterinary Medicine, Kansas State University, 1600 Denison Ave, Manhattan, KS 66506, USA
    • ,
  • Atsushi Kawabata

      Affiliations

    • Department of Anatomy & Physiology, College of Veterinary Medicine, Kansas State University, 1600 Denison Ave, Manhattan, KS 66506, USA
    • ,
  • Marla M. Pyle

      Affiliations

    • Department of Anatomy & Physiology, College of Veterinary Medicine, Kansas State University, 1600 Denison Ave, Manhattan, KS 66506, USA
    • ,
  • Lara Pickel

      Affiliations

    • Department of Anatomy & Physiology, College of Veterinary Medicine, Kansas State University, 1600 Denison Ave, Manhattan, KS 66506, USA
    • ,
  • Jennifer Reischman

      Affiliations

    • Department of Anatomy & Physiology, College of Veterinary Medicine, Kansas State University, 1600 Denison Ave, Manhattan, KS 66506, USA
    • ,
  • Frank Marini

      Affiliations

    • Department of Blood and Marrow Transplantation, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA
    • ,
  • Deryl Troyer

      Affiliations

    • Department of Anatomy & Physiology, College of Veterinary Medicine, Kansas State University, 1600 Denison Ave, Manhattan, KS 66506, USA
    • ,
  • Masaaki Tamura

      Affiliations

    • Department of Anatomy & Physiology, College of Veterinary Medicine, Kansas State University, 1600 Denison Ave, Manhattan, KS 66506, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 785 532 4825; fax: +1 785 532 4557.

Received 30 June 2009 ,Revised 18 December 2009 ,Accepted 5 January 2010.

References 

  1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics, 2009. CA Cancer J Clin. 2009;
  2. Wong VL, Rieman DJ, Aronson L, Dalton BJ, Greig R, Anzano MA. Growth-inhibitory activity of interferon-beta against human colorectal carcinoma cell lines. Int J Cancer. 1989;43:526–530
  3. Zhang H, Koty PP, Mayotte J, Levitt ML. Induction of multiple programmed cell death pathways by IFN-beta in human non-small-cell lung cancer cell lines. Exp Cell Res. 1999;247:133–141
  4. Chawla-Sarkar M, Leaman DW, Borden EC. Preferential induction of apoptosis by interferon (IFN)-beta compared with IFN-alpha2: correlation with TRAIL/Apo2L induction in melanoma cell lines. Clin Cancer Res. 2001;7:1821–1831
  5. Xu L, Xie K, Fidler IJ. Therapy of human ovarian cancer by transfection with the murine interferon beta gene: role of macrophage-inducible nitric oxide synthase. Hum Gene Ther. 1998;9:2699–2708
  6. Izawa JI, Sweeney P, Perrotte P, Kedar D, Dong Z, Slaton JW, et al. Inhibition of tumorigenicity and metastasis of human bladder cancer growing in athymic mice by interferon-beta gene therapy results partially from various antiangiogenic effects including endothelial cell apoptosis. Clin Cancer Res. 2002;8:1258–1270
  7. Nakahara N, Pollack IF, Storkus WJ, Wakabayashi T, Yoshida J, Okada H. Effective induction of antiglioma cytotoxic T cells by coadministration of interferon-beta gene vector and dendritic cells. Cancer Gene Ther. 2003;10:549–558
  8. Natsume A, Mizuno M, Ryuke Y, Yoshida J. Antitumor effect and cellular immunity activation by murine interferon-beta gene transfer against intracerebral glioma in mouse. Gene Ther. 1999;6:1626–1633
  9. Wilderman MJ, Sun J, Jassar AS, Kapoor V, Khan M, Vachani A, et al. Intrapulmonary IFN-beta gene therapy using an adenoviral vector is highly effective in a murine orthotopic model of bronchogenic adenocarcinoma of the lung. Cancer Res. 2005;65:8379–8387
  10. Lang FF, Bruner JM, Fuller GN, Aldape K, Prados MD, Chang S, et al. Phase I trial of adenovirus-mediated p53 gene therapy for recurrent glioma: biological and clinical results. J Clin Oncol. 2003;21:2508–2518
  11. Studeny M, Marini FC, Dembinski JL, Zompetta C, Cabreira-Hansen M, Bekele BN, et al. Mesenchymal stem cells: potential precursors for tumor stroma and targeted-delivery vehicles for anticancer agents. J Natl Cancer Inst. 2004;96:1593–1603
  12. Studeny M, Marini FC, Champlin RE, Zompetta C, Fidler IJ, Andreeff M. Bone marrow-derived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors. Cancer Res. 2002;62:3603–3608
  13. Nakamizo A, Marini F, Amano T, Khan A, Studeny M, Gumin J, et al. Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas. Cancer Res. 2005;65:3307–3318
  14. Rachakatla RS, Marini F, Weiss ML, Tamura M, Troyer D. Development of human umbilical cord matrix stem cell-based gene therapy for experimental lung tumors. Cancer Gene Ther. 2007;14:828–835
  15. Reed JC, Pellecchia M. Apoptosis-based therapies for hematologic malignancies. Blood. 2005;106:408–418
  16. Reed JC. Drug insight: cancer therapy strategies based on restoration of endogenous cell death mechanisms. Nat Clin Pract Oncol. 2006;3:388–398
  17. Shinoura N, Yoshida Y, Sadata A, Hanada KI, Yamamoto S, Kirino T, et al. Apoptosis by retrovirus- and adenovirus-mediated gene transfer of Fas ligand to glioma cells: implications for gene therapy. Hum Gene Ther. 1998;9:1983–1993
  18. Shimizu M, Takeda Y, Yagita H, Yoshimoto T, Matsuzawa A. Antitumor activity exhibited by Fas ligand (CD95L) overexpressed on lymphoid cells against Fas+ tumor cells. Cancer Immunol Immunother. 1998;47:143–148
  19. Arai H, Gordon D, Nabel EG, Nabel GJ. Gene transfer of Fas ligand induces tumor regression in vivo. Proc Natl Acad Sci USA. 1997;94:13862–13867
  20. Gomez-Navarro J, Arafat W, Xiang J. Gene therapy for carcinoma of the breast: Pro-apoptotic gene therapy. Breast Cancer Res. 2000;2:32–44
  21. Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev. 2004;25:581–611
  22. Donegan SE, Naples KM. Epidermal growth factor receptor inhibitors: a novel anticancer therapy. Cancer Pract. 2002;10:53–56
  23. Ng SS, Tsao MS, Nicklee T, Hedley DW. Effects of the epidermal growth factor receptor inhibitor OSI-774, Tarceva, on downstream signaling pathways and apoptosis in human pancreatic adenocarcinoma. Mol Cancer Ther. 2002;1:777–783
  24. Juang SH, Wei SJ, Hung YM, Hsu CY, Yang DM, Liu KJ, et al. IFN-beta induces caspase-mediated apoptosis by disrupting mitochondria in human advanced stage colon cancer cell lines. J Interferon Cytokine Res. 2004;24:231–243
  25. Johns TG, Mackay IR, Callister KA, Hertzog PJ, Devenish RJ, Linnane AW. Antiproliferative potencies of interferons on melanoma cell lines and xenografts: higher efficacy of interferon beta. J Natl Cancer Inst. 1992;84:1185–1190
  26. Salmon P, Le Cotonnec JY, Galazka A, Abdul-Ahad A, Darragh A. Pharmacokinetics and pharmacodynamics of recombinant human interferon-beta in healthy male volunteers. J Interferon Cytokine Res. 1996;16:759–764
  27. Einhorn S, Grander D. Why do so many cancer patients fail to respond to interferon therapy?. J Interferon Cytokine Res. 1996;16:275–281
  28. Buchwalder PA, Buclin T, Trinchard I, Munafo A, Biollaz J. Pharmacokinetics and pharmacodynamics of IFN-beta 1a in healthy volunteers. J Interferon Cytokine Res. 2000;20:857–866
  29. Cho PS, Messina DJ, Hirsh EL, Chi N, Goldman SN, Lo DP, et al. Immunogenicity of umbilical cord tissue derived cells. Blood. 2008;111:430–438
  30. Weiss ML, Anderson C, Medicetty S, Seshareddy KB, Weiss RJ, Vanderwerff I, et al. Immune properties of human umbilical cord Wharton's jelly-derived cells. Stem Cells. 2008;
  31. Nakamura K, Ito Y, Kawano Y, Kurozumi K, Kobune M, Tsuda H, et al. Antitumor effect of genetically engineered mesenchymal stem cells in a rat glioma model. Gene Ther. 2004;11:1155–1164
  32. Azizi SA, Stokes D, Augelli BJ, DiGirolamo C, Prockop DJ. Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats—similarities to astrocyte grafts. Proc Natl Acad Sci USA. 1998;95:3908–3913
  33. Kopen GC, Prockop DJ, Phinney DG. Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc Natl Acad Sci USA. 1999;96:10711–10716
  34. Weiss ML, Medicetty S, Bledsoe AR, Rachakatla RS, Choi M, Merchav S, et al. Human umbilical cord matrix stem cells: preliminary characterization and effect of transplantation in a rodent model of Parkinson's disease. Stem Cells. 2006;24:781–792
  35. Ayuzawa A, Doi C, Rachakatla RS, Pyle MM, Maurya DK, Troyer D, et al. Naïve human umbilical cord matrix derived stem cells significantly attenuate growth of human breast cancer cells in vitro and in vivo. Cancer Lett. 2009;280:31–37
  36. Ganta C, Chiyo D, Ayuzawa R, Rachakatla R, Pyle M, Andrews G, et al. Rat umbilical cord stem cells completely abolish rat mammary carcinomas with no evidence of metastasis or recurrence 100 days post-tumor cell inoculation. Cancer Res. 2009;69:1815–1820
  37. Mitchell KE, Weiss ML, Mitchell BM, Martin P, Davis D, Morales L, et al. Matrix cells from Wharton's jelly form neurons and glia. Stem Cells. 2003;21:50–60
  38. Weiss ML, Troyer DL. Stem cells in the umbilical cord. Stem Cell Rev. 2006;2:155–162

PII: S0169-5002(10)00005-X

doi: 10.1016/j.lungcan.2010.01.003

Lung Cancer
Volume 70, Issue 1 , Pages 28-36 , October 2010

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