Lung Cancer
Volume 70, Issue 2 , Pages 188-194 , November 2010

Phase I study of autologous dendritic cell tumor vaccine in patients with non-small cell lung cancer

  • Soo-Jung Um

      Affiliations

    • Department of Internal Medicine, Dong-A University College of Medicine, 3-Ga Dongdaeshin-dong, Seo-gu, Busan 602-715, Republic of Korea
    • Both these authors contributed equally to this paper.
    • ,
  • Young Jin Choi

      Affiliations

    • Department of Internal Medicine, Pusan National University School of Medicine, Ami-dong, Seo-gu, Busan, Republic of Korea
    • ,
  • Ho-Jin Shin

      Affiliations

    • Department of Internal Medicine, Pusan National University School of Medicine, Ami-dong, Seo-gu, Busan, Republic of Korea
    • ,
  • Cheol Hun Son

      Affiliations

    • Binex Research Institute, Binex Co. Ltd., Busan, Republic of Korea
    • ,
  • You-Soo Park

      Affiliations

    • Binex Research Institute, Binex Co. Ltd., Busan, Republic of Korea
    • ,
  • Mee Sook Roh

      Affiliations

    • Department of Pathology, Dong-A University College of Medicine, Busan, Republic of Korea
    • ,
  • Yun Seong Kim

      Affiliations

    • Department of Internal Medicine, Pusan National University School of Medicine, Ami-dong, Seo-gu, Busan, Republic of Korea
    • ,
  • Young Dae Kim

      Affiliations

    • Department of Thoracic Surgery, Pusan National University School of Medicine, Busan, Republic of Korea
    • ,
  • Soo-Keol Lee

      Affiliations

    • Department of Internal Medicine, Dong-A University College of Medicine, 3-Ga Dongdaeshin-dong, Seo-gu, Busan 602-715, Republic of Korea
    • ,
  • Min Ho Jung

      Affiliations

    • Department of Microbiology, Dong-A University College of Medicine, Busan, Republic of Korea
    • ,
  • Min Ki Lee

      Affiliations

    • Department of Internal Medicine, Pusan National University School of Medicine, Ami-dong, Seo-gu, Busan, Republic of Korea
    • Both these authors contributed equally to this paper.
    • ,
  • Choonhee Son

      Affiliations

    • Department of Internal Medicine, Dong-A University College of Medicine, 3-Ga Dongdaeshin-dong, Seo-gu, Busan 602-715, Republic of Korea
    • Corresponding Author InformationCorresponding author. Tel.: +82 51 240 2874; fax: +82 51 242 5852.
    • ,
  • Pil Jo Choi

      Affiliations

    • Department of Thoracic and Cardio-vascular Surgery, Dong-A University College of Medicine, Busan, Republic of Korea
    • ,
  • Jooseop Chung

      Affiliations

    • Department of Internal Medicine, Pusan National University School of Medicine, Ami-dong, Seo-gu, Busan, Republic of Korea
    • Corresponding Author InformationCo-corresponding author.
    • ,
  • Chi-Dug Kang

      Affiliations

    • Department of Biochemistry, Pusan National University School of Medicine, Busan, Republic of Korea
    • ,
  • Eun-Yup Lee

      Affiliations

    • Department of Laboratory Medicine, Pusan National University School of Medicine, Busan, Republic of Korea

Received 16 October 2009 ,Revised 8 February 2010 ,Accepted 9 February 2010.

References 

  1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statics, 2002. CA: Cancer J Clin. 2005;55:74–108
  2. http://ups.kosis.kr/upload/magazine/new/yd/vd0006.xls
  3. Spira A, Ettinger DS. Multidisciplinary management of lung cancer. N Engl J Med. 2004;350:379–392
  4. Dunn GP, Bruce AT, Ikeda H, Old LJ, Schreiber RD. Cancer immuno editing: from immunosurveillance to tumor espcape. Nat Immunol. 2002;3:991–998
  5. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature. 1998;392:245–252
  6. Gilboa E, Nair SK, Lyerly HK. Immunotherapy of cancer with dendritic cell based vaccines. Cancer Immunol Immunother. 1998;46:82–87
  7. Cranmer LD, Trevor KT, Hersh EM. Clinical applications of dendritic cell vaccination in the treatment of cancer. Cancer Immunol Immunother. 2004;53:275–306
  8. Tarte K, Klein B. Dendritic cell-based vaccine: a promising approach for cancer immunotherapy. Leukemia. 1999;13:653–663
  9. Kim KW, Kim SH, Jang JH, Lee EY, Park SW, Um JH, et al. Dendritic cells loaded with exogenous antigen by electroporation can enhance MHC class I-mediated antitumor immunity. Cancer Immunol Immunother. 2004;53:315–322
  10. National Cancer Institute. National Cancer Institute common toxicity criteria. http://ctep.info.nih.gov/reporting/index.html [on-line].
  11. Therasse P, Arbuck SG, Eisenhauer EA, Wanders J, Kaplan RS, Rubinstein L, et al. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Nat Cancer Inst. 2000;92:205–216
  12. Mukherji B, Chakraborty NG, Yamasaki S, Okina T, Yamase H, Sporn JR, et al. Induction of antigen-specific cytolytic T cells in situ in human melanoma by immunization with synthetic peptide-pulsed autologous antigen presenting cells. Proc Natl Acad Sci USA. 1995;9:8078–8082
  13. Ridgway D. The first 1000 dendritic cell vaccines. Cancer Invest. 2003;21:873–886
  14. Keilholz U, Weber J, Finke JH, Gabrilovich DI, Kast WM, Disis ML, et al. Immunologic monitoring of cancer vaccine therapy: results of a workshop sponsored by the Society for Biological Therapy. J Immunother. 2002;25:97–138
  15. Nemunaitis J, Sterman D, Jablons D, Smith JW, Fox B, Maples P, et al. Granulocyte-macrophage colony-stimulating factor gene-modified autologous tumor vaccines in non-small-cell lung cancer. J Natl Cancer Inst. 2004;96:326–331
  16. Conrad C, Nestle FO. Dendritic cell-based cancer therapy. Curr Opin Mol Ther. 2003;5:405–412
  17. Reid DC. Dendritic cells and immunotherapy for malignant disease. Br J Haematol. 2001;112:874–887
  18. Morse MA, Coleman RE, Akabani G, Niehaus N, Coleman D. Lyerly HK migration of human dendritic cells after injection in patients with metastatic malignancies. Cancer Res. 1999;59:56–58
  19. Fong L, Brockstedt D, Benike C, Wu L, Engleman EG. Dendritic cells injected via different routes induce immunity in cancer patients. J Immunol. 2001;166:4254–4259
  20. Hirschowitz EA, Foody T, Kryscio R, Dickson L, Sturgill J, Yannelli J. Autologous dendritic cell vaccines for non-small-cell lung cancer. J Clin Oncol. 2004;22:2808–2815
  21. Avigan DE, Vasir B, George DJ, Oh WK, Atkins MB, McDermott DF, et al. Phase I/II study of vaccination with electrofused allogeneic dendritic cells/autologous tumor-derived cells in patients with stage IV renal cell carcinoma. J Immunother. 2007;30:749–761
  22. Chang AE, Redman BG, Whitfield JR, Nickoloff BJ, Braun TM, Lee PP, et al. A phase I trial of tumor lysate-pulsed dendritic cells in the treatment of advanced cancer. Clin Cancer Res. 2002;8:1021–1032

PII: S0169-5002(10)00071-1

doi: 10.1016/j.lungcan.2010.02.006

Lung Cancer
Volume 70, Issue 2 , Pages 188-194 , November 2010

Article Tools

* Image Usage & Resolution