The platinum-based treatments for advanced non-small cell lung cancer, is low/negative ERCC1 expression better than high/positive ERCC1 expression? A meta-analysis

Chen, Sufeng; Zhang, Jie; Wang, Rui; Luo, Xiaoyang; Chen, Haiquan

doi:10.1016/j.lungcan.2010.05.010

« Previous Next »Lung Cancer
Volume 70, Issue 1 , Pages 63-70, October 2010

The platinum-based treatments for advanced non-small cell lung cancer, is low/negative ERCC1 expression better than high/positive ERCC1 expression? A meta-analysis

Sufeng Chen
- Department of Cardiothoracic Surgery, The Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 600 Yishan Road, Shanghai 200233, People's Republic of China
- These two authors contributed equally to this paper.
Jie Zhang
- Department of Thoracic Surgery, Cancer Hospital of Fudan University, 399 Ling Lin Street, Shanghai 200032, People's Republic of China
- These two authors contributed equally to this paper.
Rui Wang
- Department of Thoracic Surgery, Cancer Hospital of Fudan University, 399 Ling Lin Street, Shanghai 200032, People's Republic of China
Xiaoyang Luo
- Department of Thoracic Surgery, Cancer Hospital of Fudan University, 399 Ling Lin Street, Shanghai 200032, People's Republic of China
Haiquan Chen
- Department of Cardiothoracic Surgery, The Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 600 Yishan Road, Shanghai 200233, People's Republic of China
- Department of Thoracic Surgery, Cancer Hospital of Fudan University, 399 Ling Lin Street, Shanghai 200032, People's Republic of China
- Corresponding author at: Department of Thoracic Surgery, Cancer Hospital of Fudan University, 399 Ling Lin Street, Shanghai 200032, People's Republic of China. Tel.: +86 136 0197 3588; fax: +86 21 5635 3642.

Received 24 October 2009; received in revised form 1 May 2010; accepted 7 May 2010. published online 11 June 2010.

Abstract

Background

The predictive value of ERCC1 for prognosis and sensitivity to platinum-based chemotherapy in patients with non-small cell lung cancer (NSCLC) remains controversial. This meta-analysis was performed to provide an assessment of whether expression variations of ERCC1 are associated with objective response and median survival in patients with advanced NSCLC treated with platinum-based chemotherapy.

Methods

We searched MEDLINE, EMBASE and CNKI for all eligible studies and conducted a meta-analysis of 12 studies (n=836 patients) that evaluated the correlation between ERCC1 levels (detected by immunohistochemistry or real-time reverse transcriptase PCR) and objective response or median survival in patients receiving platinum-based chemotherapy for advanced NSCLC. Pooled odds ratios (OR) for the objective response were calculated using the Mantel–Haenszel method. Pooled median ratios for median survival were calculated using the weighted sum of the log-ratio of median ratios from each individual study.

Results

Among 836 tumors, ERCC1 expression was high/positive in 416 (49.8%) and low/negative in 420 (50.2%). Response to platinum-based chemotherapy was significantly higher in patients with ERCC1 low/negative expression (OR=0.48; 95% CI, 0.35–0.64; P<0.00001). Median survival time was significantly prolonged when ERCC1 low/negative expression was compared with ERCC1 high/positive expression (MR: 0.77; 95% CI, 0.47–1.07; P<0.00001).

Conclusions

Low/negative expression of ERCC1 was associated with higher objective response and median survival in advanced NSCLC patients treated with platinum-based chemotherapy. ERCC1 may be a suitable marker of prognosis and sensitivity to platinum-based chemotherapy in patients with advanced NSCLC.

Keywords: Carcinoma, Chemotherapy, ERCC1, Meta-analysis, Non-small-cell lung, Survival