Lung Cancer
Volume 72, Issue 1 , Pages 108-113 , April 2011

Prognostic impact of comorbidity in elderly lung cancer patients: Use and comparison of two scores

  • Regina Gironés

      Affiliations

    • Medical Oncology Unit, Hospital Lluís Alcanyís, Xàtiva, Spain
    • Corresponding Author InformationCorresponding author at: Medical Oncology Unit, Hospital Lluís Alcanyís, Crta Xativa a Silla km 2, 46800 Xativa, Valencia, Spain. Tel.: +34 96 228 95 79.
  • ,
  • Dolores Torregrosa

      Affiliations

    • Medical Oncology Unit, Hospital Lluís Alcanyís, Xàtiva, Spain
  • ,
  • José Gómez-Codina

      Affiliations

    • Medical Oncology Service, University Hospital La Fe, Valencia, Spain
  • ,
  • Inma Maestu

      Affiliations

    • Medical Oncology Unit, Hospital Doctor Peset, Valencia, Spain
  • ,
  • Jose Mª. Tenias

      Affiliations

    • Investigation Unit from La Mancha Centro Hospital, Alcázar de San, Juan, Ciudad Real, Spain
  • ,
  • Rafael Rosell

      Affiliations

    • Medical Oncology Service, Oncology Research, Catalan Institute of Oncology, Hospital Germans Trias i Pujol, Spain

Received 20 March 2010 ,Revised 28 June 2010 ,Accepted 4 July 2010.

References 

  1. Birim O, Kappetein AP, Bogers JJC. Charlson comorbidity index as a predictor of long-term outcome after surgery for non-small cell lung cancer. Eur J Cardio-thoracic Surg. 2005;28:759–762
  2. Janssen-Heijnen ML, Smulders S, Lemmens VE, Smeenk FW, van Geffen HJ, Coebergh JW. Effect of comorbidity on the treatment and prognosis of elderly patients with non-small cell lung cancer. Thorax. 2004;59:602–607
  3. Charlson M, Szatrowski TP, Peterson , Gold J. Validation of a combined comorbidity index. J Clin Epidemiol. 1994;47:1245–1251
  4. Colinet B, Jacot W, Bertrand D, Lacombe S, Bozonnat M-C, Daurès J-P, et al. A new simplified comorbidity score as a prognostic factor in non-small-cell lung cancer patients: description and comparison with the Charlson's index. Br J Cancer. 2005;93:1098–1105
  5. Extermann M, Overcash J, Lyman GH, Parr J, Balducci L. Comorbidity and functional status are independent in older cancer patients. J Clin Oncol. 1998;16:1582–1587
  6. Domingo E, Suriñach JM, Murillo J, Duran M, Suriñach J, Baselga J, et al. Prognostic factors in the diagnostic work-up of cancer patients in an internal medicine department: does age matter?. Int J Clin Pract. 2008;62(11):1723–1729
  7. Jacot W, Colinet B, Bertrand D, Lacombe S, Bozonnat M-C, Daurès J-P, et al. Quality of life and comorbidity score as prognostic determinants in non-small-cell lung cancer patients. Ann Oncol. 2008;19:1458–1464
  8. Hervé LeCaer , Barlesi F, Robinet G, Fournel P, Geriniere L, Bombaron P, et al. An open multicenter phase II trial of weekly docetaxel for advanced-stage non-small-cell lung cancer in elderly patients with significant comorbidity and/or poor performance status: the GFPC 02-02b study. Lung Cancer. 2007;57:72–78
  9. Zubrod CG. Origins and development of chemotherapy research at the National Cancer Institute. Cancer Treat Rep. 1984;68(1):9–19
  10. Balducci L, Extermann M. Management of cancer in the older person: a practical approach. Oncologist. 2000;5:224–237
  11. Rao AV, Pearl HS, Cohen HJ. Geriatric assessment and comorbidity. Semin Oncol. 2004;31(2):149–159
  12. Aapro M, kohne CH, Cohen HJ, Extermann M. Never too old? Age should be a barrier to enrollment in cancer clinical trials. Oncologist. 2005;10:198–204
  13. Extermann M, Aapro M, Bernabei R, Cohen HJ, Droz JP, Lichtman S, et al. Use of comprehensive geriatric assessment in older cancer patients: recommendations from the task force on CGA of the International Society of Geriatric Oncology (SIOG). Crit Rev Oncol Hematol. 2005;55(3):241–252
  14. Maestu I, Muñoz J, Gómez-Aldaravi L, Esquerdo G, Yubero A, Torregrosa MD, et al. Assessment of functional status, symptoms and comorbidity in elderly patients with advanced non-small-cell lung cancer (NSCLC) treated with gemcitabine and vinorelbine. Clin Transl Oncol. 2007;9:99–105
  15. Ambrogi V, Pompeo E, Elia E, Pistolese GR, Mineo TC. The impact of cardiovascular comorbidity on the outcome of surgery for stages I and II non-small-cell lung cancer. Eur J Cardio-Thorac Surg. 2003;23:811–817
  16. Ludbrook JJS, Truong PT, MacNeil MV, Lesperance M, Webber A, Joe H, et al. Do age and comorbidity impact treatment allocation and outcomes in limited stage small-cell lung cancer? A community-based population analysis. Int J Radiat Oncol Biol Phys. 2003;55:1321–1330
  17. Firat S, Bousamra M, Gore E, Byhardt RW. Comorbidity and KPS are independent prognostic factors in stage I non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2002;52:1047–1057
  18. Firat S, Pleister A, Byhardt RW, Gore E. Age is independent of comorbidity influencing patient selection for combined modality therapy for treatment of stage III non-small cell lung cancer (NSCLC). Am J Clin Oncol. 2006;29:252–257
  19. Battafarano RJ, Piccirillo JF, Meyers BF, Hsu HS, Guthrie TJ, Cooper JD, et al. Impact of comorbidity on survival after surgical resection in patients with stage I non-small cell lung cancer. J Thorac Cardiovasc Surg. 2002;123:280–287
  20. Tammemagi CM, Neslund-Dudas C, Simoff M, Kvale P. Impact of comorbidity on lung cancer survival. Int J Cancer. 2003;103:792–802
  21. Asmis TR, Ding K, Seymour L, Shepherd FA, Leighl NB, Witehead M, et al. Age and comorbidity as independent prognostic factors in the treatment of non-small-cell lung cancer: a review of National Cancer Institute of Canada Clinical Trials Group Trials. J Clin Oncol. 2008;26:54–59
  22. Miyazaki K, Kikuchi N, Satoh H, Sekizawa K, Janssen-Heijnen MLG, Coebergh JWW. Comorbidity in elderly NSCLC patients. Thorax. 2005;60:704
  23. Piccirillo JF, Tierney RM, Costas I, Grove L, Spitznagel EL. Prognostic importance of comorbidity in a hospital-based cancer registry. JAMA. 2004;291:2441–2447
  24. Read WL, Tierney RM, Page NC, Costas I, Govidan R, Spitznagel ELJ, et al. Differential prognostic impact of comorbidity. J Clin Oncol. 2004;22:3099–3103

PII: S0169-5002(10)00333-8

doi: 10.1016/j.lungcan.2010.07.001

Lung Cancer
Volume 72, Issue 1 , Pages 108-113 , April 2011