Lung Cancer
Volume 72, Issue 1 , Pages 78-83 , April 2011

Intrapleural administration of lipoplatin in an animal model

  • Marios E. Froudarakis

      Affiliations

    • Department of Pneumonology, Medical School Democritus University of Thrace, Greece
    • Faculté de Médecine, Université de la Méditerranée, Assistance Publique Hôpitaux de Marseille, Service d’Oncologie Thoracique, Hôpital Sainte-Marguerite, Marseille, France
    • Corresponding Author InformationCorresponding author at: Faculté de Médecine, Université de la Méditerranée, Assistance Publique Hôpitaux de Marseille, Service d’Oncologie Thoracique, Hôpital Sainte-Marguerite, 270, Bd de Ste-Marguerite, 13274 Marseille, Cedex 09, France.
    • ,
  • Laurent Greillier

      Affiliations

    • Faculté de Médecine, Université de la Méditerranée, Assistance Publique Hôpitaux de Marseille, Service d’Oncologie Thoracique, Hôpital Sainte-Marguerite, Marseille, France
    • ,
  • Suzanne Monjanel-Mouterde

      Affiliations

    • Assistance Publique Hôpitaux de Marseille, Laboratoire de Pharmacocinétique et de Toxicologie, Hôpital de la Timone Adultes, Marseille, France
    • Faculté de Pharmacie, Université de la Méditerranée, Laboratoire de Pharmacodynamie, Marseille, France
    • ,
  • Anastassios Koutsopoulos

      Affiliations

    • Department of Pathology, Medical School Democritus University of Thrace, Greece
    • ,
  • Benedicte Devictor-Pierre

      Affiliations

    • Department of Pneumonology, Medical School Democritus University of Thrace, Greece
    • Faculté de Médecine, Université de la Méditerranée, Assistance Publique Hôpitaux de Marseille, Service d’Oncologie Thoracique, Hôpital Sainte-Marguerite, Marseille, France
    • Assistance Publique Hôpitaux de Marseille, Laboratoire de Pharmacocinétique et de Toxicologie, Hôpital de la Timone Adultes, Marseille, France
    • Faculté de Pharmacie, Université de la Méditerranée, Laboratoire de Pharmacodynamie, Marseille, France
    • Department of Pathology, Medical School Democritus University of Thrace, Greece
    • ,
  • Romain Guilhaumou

      Affiliations

    • Department of Pneumonology, Medical School Democritus University of Thrace, Greece
    • Faculté de Médecine, Université de la Méditerranée, Assistance Publique Hôpitaux de Marseille, Service d’Oncologie Thoracique, Hôpital Sainte-Marguerite, Marseille, France
    • Assistance Publique Hôpitaux de Marseille, Laboratoire de Pharmacocinétique et de Toxicologie, Hôpital de la Timone Adultes, Marseille, France
    • Faculté de Pharmacie, Université de la Méditerranée, Laboratoire de Pharmacodynamie, Marseille, France
    • Department of Pathology, Medical School Democritus University of Thrace, Greece
    • ,
  • Georgia Karpathiou

      Affiliations

    • Department of Pathology, Medical School Democritus University of Thrace, Greece
    • ,
  • Sotirios Botaitis

      Affiliations

    • Department of Pneumonology, Medical School Democritus University of Thrace, Greece
    • ,
  • Philippe Astoul

      Affiliations

    • Faculté de Médecine, Université de la Méditerranée, Assistance Publique Hôpitaux de Marseille, Service d’Oncologie Thoracique, Hôpital Sainte-Marguerite, Marseille, France

Received 7 March 2010 ,Revised 5 July 2010 ,Accepted 26 July 2010.

References 

  1. Froudarakis ME. Diagnostic work-up of pleural effusions. Respiration. 2008;75(1):4–13
  2. Barbieri V, Tassone P, Tagliaferri P. The IASLC lung cancer staging project: revision proposal of pleural effusion and controlateral nodule staging. J Thorac Oncol. 2008;3(3 (March)):317;[author reply-8]
  3. Barlesi F, Pujol JL. Combination of chemotherapy without platinum compounds in the treatment of advanced non-small cell lung cancer: a systematic review of phase III trials. Lung Cancer. 2005;49(3 (September)):289–298
  4. Perez RP. Cellular and molecular determinants of cisplatin resistance. Eur J Cancer. 1998;34(10):1535–1542
  5. Hotta K, Matsuo K, Ueoka H, Kiura K, Tabata M, Tanimoto M. Meta-analysis of randomized clinical trials comparing cisplatin to carboplatin in patients with advanced non-small-cell lung cancer. J Clin Oncol. 2004;22(19 (October)):3852–3859
  6. Ismail-Khan R, Robinson LA, Williams CCJ, Garrett CR, Bepler G, Simon GR. Malignant pleural mesothelioma: a comprehensive review. Cancer Control. 2006;13:255–263
  7. Robinson BWS, Musk AW, Lake RA. Malignant mesothelioma. Lancet. 2005;366:397–408
  8. Vogelzang NJ, Rusthoven JJ, Symanowski J, Denham C, Kaukel E, Ruffie P, et al. Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J Clin Oncol. 2003;21(14 (July)):2636–2644
  9. Rinaldi DA, Burris HA, Dorr FA, Woodworth JR, Kuhn JG, Eckardt JR, et al. Initial phase I evaluation of the novel thymidylate synthase inhibitor. LY231514, using the modified continual reassessment method for dose escalation. J Clin Oncol. 1995;13(11 (November)):2842–2850
  10. Takimoto CH. Antifolates in clinical development. Semin Oncol. 1997;24(5 Suppl. 18 (October)):S18-40–51
  11. Boulikas T. Low toxicity and anticancer activity of a novel liposomal cisplatin (lipoplatin) in mouse xenografts. Oncol Rep. 2004;12(1 (July)):3–12
  12. Boulikas T, Stathopoulos GP, Volakakis N, Vougiouka M. Systemic lipoplatin infusion results in preferential tumor uptake in human studies. Anticancer Res. 2005;25(4 (July–August)):3031–3039
  13. Stathopoulos GP, Boulikas T, Vougiouka M, Deliconstantinos G, Rigatos S, Darli E, et al. Pharmacokinetics and adverse reactions of a new liposomal cisplatin (lipoplatin): phase I study. Oncol Rep. 2005;13(4 (April)):589–595
  14. Froudarakis ME, Pataka A, Pappas P, Anevlavis S, Argiana E, Nikolaidou M, et al. Phase 1 trial of lipoplatin and gemcitabine as a second-line chemotherapy in patients with nonsmall cell lung carcinoma. Cancer. 2008;113(10 (November)):2752–2760
  15. Karpathiou G, Argiana E, Koutsopoulos A, Froudarakis ME. Response of a patient with pleural and peritoneal mesothelioma after second-line chemotherapy with lipoplatin and gemcitabine. Oncology. 2007;73(5–6):426–429
  16. Dedrick RL, Myers CE, Bungay PM, DeVita VT. Pharmacokinetic rationale for peritoneal drug administration in the treatment of ovarian cancer. Cancer Treat Rep. 1978;62(1 (January)):1–11
  17. Markman M. Intracavitary chemotherapy. Curr Probl Cancer. 1986;10(8 (August)):401–437
  18. Monjanel-Mouterde S, Frenay C, Catalin J, Boutin C, Durand A, Astoul P. Pharmacokinetics of intrapleural cisplatin for the treatment of malignant pleural effusions. Oncol Rep. 2000;7(1 (January–February)):171–175
  19. Lerza R, Vannozzi MO, Tolino G, Viale M, Bottino GB, Bogliolo G, et al. Carboplatin and cisplatin pharmacokinetics after intrapleural combination treatment in patients with malignant pleural effusion. Ann Oncol. 1997;8(4 (April)):385–391
  20. Holoye PY, Jeffries DG, Dhingra HM, Holmes FA, Raber M, Engineer MS, et al. Intrapleural etoposide for malignant effusion. Cancer Chemother Pharmacol. 1990;26(2):147–150
  21. Perng RP, Wu MF, Lin SY, Chen YM, Lin JY, Whang-Peng J. A phase I feasibility and pharmacokinetic study of intrapleural paclitaxel in patients with malignant pleural effusions. Anticancer Drugs. 1997;8(6 (July)):565–573
  22. Greillier L, Monjanel-Mouterde S, Fraticelli A, Devictor-Pierre B, Bouvenot J, Coltel N, et al. Intrapleural administration of pemetrexed: a pharmacokinetic study in an animal model. J Thorac Oncol. 2009;4(3 (March)):404–408
  23. Freireich EJ, Gehan EA, Rall DP, Schmidt LH, Skipper HE. Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man. Cancer Chemother Rep. 1966;50(4 (May)):219–244
  24. Perez-Soler R, Shin DM, Siddik ZH, Murphy WK, Huber M, Lee SJ, et al. Phase I clinical and pharmacological study of liposome-entrapped NDDP administered intrapleurally in patients with malignant pleural effusions. Clin Cancer Res. 1997;3(3 (March)):373–379
  25. Iliadis A, Brown AC, Huggins ML. APIS: a software for model identification, simulation and dosage regimen calculations in clinical and experimental pharmacokinetics. Comput Methods Programs Biomed. 1992;38(4 (August)):227–239
  26. Nishina K, Mikawa K, Takao Y, Shiga M, Maekawa N, Obara H. Intravenous lidocaine attenuates acute lung injury induced by hydrochloric acid aspiration in rabbits. Anesthesiology. 1998;88(5 (May)):1300–1309
  27. Colt HG, Russack V, Chiu Y, Konopka RG, Chiles PG, Pedersen CA, et al. A comparison of thoracoscopic talc insufflation, slurry, and mechanical abrasion pleurodesis. Chest. 1997;111(2 (February)):442–448
  28. Vadiei K, Siddik ZH, Khokhar AR, al-Baker S, Sampedro F, Perez-Soler R. Pharmacokinetics of liposome-entrapped cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane platinum(II) and cisplatin given i.v. and i.p. in the rat. Cancer Chemother Pharmacol. 1992;30(5):365–369
  29. Astoul P, Bertault-Peres P, Durand A, Catalin J, Vignal F, Boutin C. Pharmacokinetics of intrapleural recombinant interleukin-2 in immunotherapy for malignant pleural effusion. Cancer. 1994;73(2 (January)):308–313
  30. Lu C, Perez-Soler R, Piperdi B, Walsh GL, Swisher SG, Smythe WR, et al. Phase II study of a liposome-entrapped cisplatin analog (L-NDDP) administered intrapleurally and pathologic response rates in patients with malignant pleural mesothelioma. J Clin Oncol. 2005;23(15 (May)):3495–3501
  31. Seto T, Ushijima S, Yamamoto H, Ito K, Araki J, Inoue Y, et al. Intrapleural hypotonic cisplatin treatment for malignant pleural effusion in 80 patients with non-small-cell lung cancer: a multi-institutional phase II trial. Br J Cancer. 2006;95(6 (September)):717–721
  32. Boulikas T. Clinical overview on lipoplatin: a successful liposomal formulation of cisplatin. Expert Opin Investig Drugs. 2009;18(8 (August)):1197–1218
  33. Elit L, Oliver TK, Covens A, Kwon J, Fung MF, Hirte HW, et al. Intraperitoneal chemotherapy in the first-line treatment of women with stage III epithelial ovarian cancer: a systematic review with metaanalyses. Cancer. 2007;109(4 (February)):692–702

PII: S0169-5002(10)00373-9

doi: 10.1016/j.lungcan.2010.07.010

Lung Cancer
Volume 72, Issue 1 , Pages 78-83 , April 2011

Article Tools

* Image Usage & Resolution